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PROS1 抗体

PROS 适用: 人 WB, FACS 宿主: 大鼠 Monoclonal PS7 unconjugated
产品编号 ABIN2192011
发货至: 中国
  • 抗原 See all PROS1 (PROS) 抗体
    PROS1 (PROS) (Protein S (PROS))
    适用
    • 76
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    • 1
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    宿主
    • 50
    • 11
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    大鼠
    克隆类型
    • 67
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    单克隆
    标记
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    This PROS1 antibody is un-conjugated
    应用范围
    • 61
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    Western Blotting (WB), Flow Cytometry (FACS)
    过滤
    0.2 μm filtered
    克隆位点
    PS7
    Top Product
    Discover our top product PROS Primary Antibody
  • 应用备注
    For flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
    限制
    仅限研究用
  • 缓冲液
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    有效期
    12 months
  • 抗原
    PROS1 (PROS) (Protein S (PROS))
    别名
    Protein S (PROS 产品)
    别名
    PROS antibody, PS21 antibody, PS22 antibody, PS23 antibody, PS24 antibody, PS25 antibody, PSA antibody, THPH5 antibody, THPH6 antibody, zgc:154001 antibody, AW214361 antibody, protein S antibody, protein S (alpha) antibody, PROS1 antibody, Pros1 antibody, pros1 antibody
    背景
    Monoclonal antibody PS7 is specific for human Protein S (PS), a vitamin K-dependent plasma glycoprotein with a molecular weight of approximately 70 kDa. In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)-like domains, and a sex hormone-binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain. Monoclonal antibody PS7 allows specific detection of cells carrying PS by flow cytometry. Aliases PROS1
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