CD166 抗体
(4 references)-
- 抗原 See all CD166 (ALCAM) 抗体
- CD166 (ALCAM) (Activated Leukocyte Cell Adhesion Molecule (ALCAM))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD166 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Functional Studies (Func)
- 过滤
- 0.2 μm filtered
- 克隆位点
- AZN-L50
- Top Product
- Discover our top product ALCAM Primary Antibody
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anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 48-216) antibody
ALCAM 适用: 人 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 8E12C7 unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 48-216) antibodyALCAM 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 4H9A5 unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 227-381) antibodyALCAM 适用: 人 WB, IHC, ELISA, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 2F1B12 unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 405-524) antibodyALCAM 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 5B3 unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 58-87) antibodyALCAM 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 28-527) antibodyALCAM 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 5-2# unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 28-527) antibodyALCAM 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 167-406) antibodyALCAM 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 451-583) antibodyALCAM 适用: 人, 兔 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 28-527) antibodyALCAM 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- For immunohistology, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule." in: Cancer research, Vol. 68, Issue 10, pp. 3671-9, (2008) (PubMed).
: "Distinct kinetic and mechanical properties govern ALCAM-mediated interactions as shown by single-molecule force spectroscopy." in: Journal of cell science, Vol. 120, Issue Pt 22, pp. 3965-76, (2007) (PubMed).
: "Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells." in: Blood, Vol. 107, Issue 8, pp. 3212-20, (2006) (PubMed).
: "Molecular basis for the homophilic activated leukocyte cell adhesion molecule (ALCAM)-ALCAM interaction." in: The Journal of biological chemistry, Vol. 276, Issue 28, pp. 25783-90, (2001) (PubMed).
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: "Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule." in: Cancer research, Vol. 68, Issue 10, pp. 3671-9, (2008) (PubMed).
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- 抗原
- CD166 (ALCAM) (Activated Leukocyte Cell Adhesion Molecule (ALCAM))
- 别名
- CD166 (ALCAM 产品)
- 背景
- The monoclonal antibody AZN-L50 recognizes activated leukocyte cell adhesion molecule (ALCAM), a member of the immunoglobulin superfamily and has a characteristic VVC2C2C2 domain structure. ALCAM is a type I transmembrane protein of 100 kDa with five extracellular immunoglobulin-like domains and a short cytoplasmic tail. ALCAM mediates homotypic ALCAM-ALCAM interactions and heterotypic interactions with the T-cell antigen CD6. Homotypic interactions are involved in the development and maintenance of tissue architecture and tumor progression. Heterotypic interactions initiate and stabilize T- cell-dendritic interactions affecting T-cell activation. ALCAM is secreted as a NH2-terminal fragment of 30 kD. Soluble ALCAM (sALCAM) induces divergent biological signals and responses. ALCAM shows a characteristic, temporal and spatial distribution in development of a wide variety of tissues and cells in health and disease. ALCAM is expressed on a wide variety of cells, within the leukocyte population its expression is particularly high on dentritic cells. ALCAM is involved in various physiological processes including hematopoieses, thymus development, the immune response, neurite extension, neural cell migration, embryogenesis, neurogenesis, angiogenesis, osteogenesis and is a marker for pluripotent mesenchymal stem cells. The monoclonal antibody AZN-L50 completely blocks homophilic ALCAM-ALCAM interaction. Aliases Activated leukocyte cell adhesion molecule, ALCAM, CD166, Immunogen CD166 expressing K562 cells
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