TREM1 抗体
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北京 101111
Quick Overview for TREM1 抗体 (ABIN2191849)
抗原
See all TREM1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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过滤
- 0.2 μm filtered
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anti-Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) (AA 21-205) antibody
TREM1 适用: 人, 大鼠, 猴 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 6B12D1 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) (AA 21-205) antibodyTREM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) (AA 21-205) antibodyTREM1 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 5F9F7 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) (AA 21-230) antibodyTREM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) (AA 21-234) antibodyTREM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E2 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) (AA 74-90) antibodyTREM1 适用: 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) (AA 21-234) antibodyTREM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F5 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) antibodyTREM1 适用: 人 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 6B1 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) antibodyTREM1 适用: 人 WB, FACS, ELISA 宿主: 小鼠 Monoclonal TREM-37 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) antibody (PE)TREM1 适用: 人 FACS 宿主: 小鼠 Monoclonal 6B1 PE
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应用备注
- For immunohistology, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting.
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限制
- 仅限研究用
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缓冲液
- PBS, containing 0.1 % bovine serum albumin.
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储存条件
- 4 °C
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储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
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有效期
- 12 months
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- TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))
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别名
- Triggering Receptor Expressed On Myeloid Cells 1
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背景
- The monoclonal antibody L5-B8 recognizes mouse triggering receptor expressed on myeloid cells-1 (TREM-1). TREM-1 is a 30 kDa monomeric transmembrane activating receptor. TREM-1 is a member of the immunoglobulin superfamily. TREM-1 is expressed at low levels in the early development of the hematopoietic system in the promonoistic stage, and at high levels on the surface of immune cells, including neutrophils, monocytes and macrofages. TREM-1 is synthesized as a 234 amino acid (aa) precursor with a signal peptide (16 aa), an extracellular domain (184 aa), a transmembrane domain (29 aa), and a short cytoplasmic domain (5 aa). The short intracellular domain associates with a signal- transduction molecule, DNAX-activation protein 12 (DAP12), triggering the secretion of inflammatory cytokines that amplify the host response to microbial agents. TREM-1 acts in synergy with Toll-like receptor signaling pathways in amplifying the inflammatory response. Platelets express a natural ligand for TREM-1. The expression of TREM-1 is greatly upregulated on phagocytic cells in the presence of bacteria and fungi. TREM-1 has a role in sepsis, inflammatory bowel disease (IBD) and multiple sclerosis. In contrast, TREM-1 is not upregulated in samples from patients with non-inefctious inflammatory conditions. During infections, receptor expression is modulated and soluble TREM-1 (sTREM-1, 17 kDa) is released. TREM-1 is shed from the membrane of activated phagocytes and can be found as sTREM-1 in body fluids like plasma and bronchoalveolar lavage fluid (BAL). Elavated levels of sTREM-1 have a accuracy and sensitivity in detecting microbial infections as underlying disease. Furthermore, sTREM-1 has been associated with non-infectious inflammatory conditions like major abdominal surgery, peptic ulcer disease and COPD. Aliases TREM-1, triggering receptor expressed on myeloid cells, TREM1 Immunogen Mouse TREM-1-human IgG-Fc fusion protein
抗原
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