OPTN 抗体 (AA 341-440) (Biotin)
Quick Overview for OPTN 抗体 (AA 341-440) (Biotin) (ABIN2178068)
抗原
See all OPTN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 341-440
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交叉反应
- 人, 小鼠
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预测反应
- Rat,Cow,Sheep
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Optineurin
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亚型
- IgG
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anti-Optineurin (OPTN) (AA 341-440) antibody
OPTN 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 1-300) antibodyOPTN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 1-577) antibodyOPTN 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Optineurin (OPTN) antibodyOPTN 适用: 人 WB, IP, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 1-577) antibodyOPTN 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 575-591) antibodyOPTN 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 1-577) antibodyOPTN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 559-575) antibodyOPTN 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 72-121) antibodyOPTN 适用: 人, 小鼠, 犬, 豚鼠, Cow, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Optineurin (OPTN) (C-Term) antibodyOPTN 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- OPTN (Optineurin (OPTN))
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别名
- Optineurin
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背景
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Synonyms: NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP, Optineurin, E3-14.7K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, OPTN
Background: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR), regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family, targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.
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基因ID
- 10133
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UniProt
- Q96CV9
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途径
- M Phase
抗原
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