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FOXA2 抗体 (AA 201-300) (PE)

FOXA2 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal PE
产品编号 ABIN2174177
发货至: 中国
  • 抗原 See all FOXA2 抗体
    FOXA2 (Forkhead Box A2 (FOXA2))
    抗原表位
    • 15
    • 14
    • 10
    • 10
    • 8
    • 8
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-300
    适用
    • 90
    • 25
    • 15
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    人, 小鼠
    宿主
    • 84
    • 7
    • 2
    克隆类型
    • 77
    • 16
    多克隆
    标记
    • 47
    • 7
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This FOXA2 antibody is conjugated to PE
    应用范围
    • 84
    • 50
    • 40
    • 25
    • 14
    • 14
    • 13
    • 10
    • 7
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    交叉反应
    人, 小鼠
    预测反应
    Rat,Cow,Pig,Horse,Chicken
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human HNF 3 beta
    亚型
    IgG
    Top Product
    Discover our top product FOXA2 Primary Antibody
  • 应用备注
    FCM 1:20-100
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • Yamamizu, Schlessinger, Ko: "SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1)." in: Development (Cambridge, England), Vol. 141, Issue 22, pp. 4254-66, (2014) (PubMed).

    Yamamizu, Fujihara, Tachibana, Katayama, Takahashi, Hara, Imai, Shinkai, Yamashita: "Protein kinase A determines timing of early differentiation through epigenetic regulation with G9a." in: Cell stem cell, Vol. 10, Issue 6, pp. 759-70, (2012) (PubMed).

  • 抗原
    FOXA2 (Forkhead Box A2 (FOXA2))
    别名
    Foxa2/Hnf 3beta (FOXA2 产品)
    别名
    hnf3b antibody, tcf3b antibody, hnf3beta antibody, hnf3-beta antibody, FOXA2 antibody, HNF3B antibody, TCF3B antibody, HNF-3B antibody, ax antibody, axl antibody, fkd1 antibody, ik:tdsubc_2g8 antibody, tdsubc_2g8 antibody, wu:fe05g04 antibody, xx:tdsubc_2g8 antibody, FoxA2-A antibody, FoxA2a antibody, xFD-3 antibody, xbeta-1 antibody, HNF-3b antibody, HNF3-beta antibody, HNF3beta antibody, Hnf-3b antibody, Hnf3b antibody, Tcf-3b antibody, Tcf3b antibody, HNF-3BETA antibody, forkhead box A2 antibody, forkhead box A2 L homeolog antibody, foxa2 antibody, FOXA2 antibody, foxa2.L antibody, Foxa2 antibody
    背景

    Synonyms: HNF3B, TCF3B, Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B, FOXA2

    Background: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs, FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis, regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

    基因ID
    3170
    UniProt
    Q9Y261
    途径
    Dopaminergic Neurogenesis, Regulation of Carbohydrate Metabolic Process
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