(4 references)-
- 抗原 See all CD1c (CD1C) 抗体
- CD1c (CD1C) (T-cell surface glycoprotein CD1c (CD1C))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD1c antibody is conjugated to PE
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The mouse monoclonal antibody L161 recognizes an extracellular epitope of CD1c, (R7), a 43 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells.
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- 免疫原
- human thymocytes
- 克隆位点
- L161
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product CD1C Primary Antibody
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anti-T-cell surface glycoprotein CD1c (CD1C) (AA 18-302) antibody
CD1C 适用: 人 ELISA, WB, FACS, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 3G1B3 unconjugated
anti-T-cell surface glycoprotein CD1c (CD1C) antibodyCD1C 适用: 人 FACS, IHC, IP 宿主: 小鼠 Monoclonal L161 unconjugated
anti-T-cell surface glycoprotein CD1c (CD1C) antibodyCD1C 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 1H9 unconjugated
anti-T-cell surface glycoprotein CD1c (CD1C) antibody (APC)CD1C 适用: 人 FACS 宿主: 小鼠 Monoclonal L161 APC
anti-T-cell surface glycoprotein CD1c (CD1C) (AA 18-300) antibodyCD1C 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-T-cell surface glycoprotein CD1c (CD1C) antibodyCD1C 适用: 人 ELISA, LMNX 宿主: 小鼠 Monoclonal OTI1F4 unconjugated
anti-T-cell surface glycoprotein CD1c (CD1C) (AA 18-302) antibodyCD1C 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-T-cell surface glycoprotein CD1c (CD1C) antibodyCD1C 适用: 人, 小鼠, 大鼠, 犬, 猴 WB 宿主: 小鼠 Monoclonal 1E10 unconjugated
anti-T-cell surface glycoprotein CD1c (CD1C) (AA 226-253) antibodyCD1C 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-T-cell surface glycoprotein CD1c (CD1C) (AA 77-185) antibodyCD1C 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- 说明
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- 限制
- 仅限研究用
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- 缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
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Do not freeze. Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user. - 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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: "The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation." in: Immunity, Vol. 33, Issue 6, pp. 853-62, (2010) (PubMed).
: "Membrane trafficking of CD1c on activated T cells." in: Journal of leukocyte biology, Vol. 70, Issue 4, pp. 567-77, (2001) (PubMed).
: "Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens." in: The Journal of experimental medicine, Vol. 192, Issue 2, pp. 281-8, (2000) (PubMed).
: "Increased numbers of dendritic cells in the bronchiolar tissues of diffuse panbronchiolitis." in: American journal of respiratory and critical care medicine, Vol. 162, Issue 1, pp. 148-53, (2000) (PubMed).
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: "The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation." in: Immunity, Vol. 33, Issue 6, pp. 853-62, (2010) (PubMed).
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- 抗原
- CD1c (CD1C) (T-cell surface glycoprotein CD1c (CD1C))
- 别名
- CD1c (CD1C 产品)
- 别名
- BDCA1 antibody, CD1 antibody, CD1A antibody, R7 antibody, CD1c molecule antibody, CD1C antibody
- 背景
- CD1c molecule,CD1c (also known as R7 or BDCA1) together with CD1a and b, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. CD1c is unique in its ability to present e.g. mycobacterial phosphoketides and polyisoprenoids. CD1c is the only CD1 isoform that has been shown to interact both with alpha/beta and gamma/delta T cells.,R7, BDCA1
- 基因ID
- 911
- UniProt
- P29017
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