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STAT3 抗体 (pTyr705)

Name: STAT3 抗体 (pTyr705)
SKU: ABIN196691
Availability: OutOfStock

This anti-STAT3 antibody is a 兔多克隆 antibody detecting STAT3 in WB 和 IHC (p). Suitable for 人和小鼠. This Primary Antibody has been cited in 9+ publications.

Image no. 2 for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pTyr705) antibody (ABIN196691) (STAT3 抗体 (pTyr705))

Image no. 1 for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pTyr705) antibody (ABIN196691) (STAT3 抗体 (pTyr705))

2 images

(9 references)

产品编号 ABIN196691

发货至: 中国

Quick Overview for STAT3 抗体 (pTyr705) (ABIN196691)

抗原

See all STAT3 抗体

STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This STAT3 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Discover our top product STAT3 Primary Antibody

抗原表位
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pTyr705

特异性

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. STAT3 (phospho-Tyr705) antibody detects endogenous levels of STAT3 only when phosphorylated at tyrosine 705.

纯化方法

Immunoaffinity chromatography.

免疫原

The antiserum was produced against synthesized phosphopeptide derived from human STAT3 around the phosphorylation site of tyrosine 705 (A-P-YP-L-K).
anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (C-Term) antibody
KO Validated STAT3 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pTyr705) antibody
STAT3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody
STAT3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (C-Term) antibody
STAT3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (AA 640-770) antibody
STAT3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (AA 233-330) antibody
STAT3 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody
STAT3 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS, IF (cc) 宿主: 兔 Monoclonal 4G1 unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (C-Term) antibody
Verified STAT3 适用: 人, 小鼠 IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (AA 670-769) antibody
STAT3 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 4D6 unconjugated

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) antibody
KO Validated STAT3 适用: 人 WB, IHC, IP, IF 宿主: 兔 Monoclonal unconjugated

应用备注

Suitable for use in Western blot (1: 500approx. 1: 1000) and Immunohistochemistry (1: 50approx. 1: 100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

1.0 mg/mL

缓冲液

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

-20 °C

储存方法

Store the antibody (in aliquots) at -20 °C.
Mpousis, Thysiadis, Avramidis, Katsamakas, Efthimiopoulos, Sarli: "Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies." in: European journal of medicinal chemistry, Vol. 108, pp. 28-38, (2016) (PubMed).

Sangaletti, Tripodo, Sandri, Torselli, Vitali, Ratti, Botti, Burocchi, Porcasi, Tomirotti, Colombo, Chiodoni: "Osteopontin shapes immunosuppression in the metastatic niche." in: Cancer research, Vol. 74, Issue 17, pp. 4706-19, (2015) (PubMed).

Ma, Li, Wang, Gong, Zhang, Li, Ji, Liu, Chen, Xiang: "Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K-Akt signaling pathways." in: Regulatory peptides, Vol. 181, pp. 9-16, (2013) (PubMed).

Wang, Peng-Jiao, Yang, Chuang-Yuan, Zhao, Liu, Fei, Zhang: "PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells." in: Toxicology letters, Vol. 220, Issue 2, pp. 150-6, (2013) (PubMed).

García-Prieto, González-López, Cabrera, Astudillo, Gutiérrez-Fernández, Fanjul-Fernandez, Batalla-Solís, Puente, Fueyo, López-Otín, Albaiceta: "Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10." in: PLoS ONE, Vol. 5, Issue 10, pp. e13242, (2010) (PubMed).

Takeichi, Sugiura, Muro, Matsumoto, Ogawa, Futamura, Kaminuma, Hashimoto, Shimoyama, Saito, Tomita: "Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition." in: The Journal of investigative dermatology, Vol. 130, Issue 12, pp. 2760-7, (2010) (PubMed).

Zhang, Zhao, Xin: "Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions." in: World journal of gastroenterology : WJG, Vol. 16, Issue 5, pp. 571-7, (2010) (PubMed).

Yuan, Qian, Shi, Lu, Li, Hu, Yu, Shen, Guo: "HER2-dependent MMP-7 expression is mediated by activated STAT3." in: Cellular signalling, Vol. 20, Issue 7, pp. 1284-91, (2008) (PubMed).

Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama: "Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation." in: Toxicology, Vol. 226, Issue 2-3, pp. 131-42, (2006) (PubMed).
抗原

STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

别名

STAT3

背景

Synonyms: APRF, Acute-phase response factor, STAT-3, Signal transducer and activator of transcription 3

基因ID

6774

NCBI登录号

NP_003141

UniProt

P40763

途径

JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor