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CCL20 抗体 (PE)

This anti-CCL20 antibody (ABIN192398) is a Mouse Monoclonal antibody detecting CCL20 in FACS. Suitable for Human.
产品编号 ABIN192398
发货至: 中国

Quick Overview for CCL20 抗体 (PE) (ABIN192398)

抗原

See all CCL20 抗体
CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CCL20 antibody is conjugated to PE

应用范围

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Flow Cytometry (FACS)

克隆位点

UCHL1
  • 原理

    Anti-Hu CD45R0 PE

    特异性

    The antibody UCHL1 recognizes an extracellular epitope of CD45R0, a 180 kDa low molecular weight isoform of the leukocyte common antigen (LCA). The antigen is expressed on a subset of memory/activated T cells and on cortical thymocytes.

    交叉反应 (详细)

    Human

    纯化方法

    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    免疫原

    Human IL-2 dependent T cells

    亚型

    IgG2a
  • 应用备注

    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

    限制

    仅限研究用
  • 溶解方式

    No reconstitution is necessary.

    缓冲液

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze.
    Avoid prolonged exposure to light.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Akbar, Terry, Timms, Beverley, Janossy: "Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 7, pp. 2171-8, (1988) (PubMed).

    Beverley, Merkenschlager, Terry: "Phenotypic diversity of the CD45 antigen and its relationship to function." in: Immunology. Supplement, Vol. 1, pp. 3-5, (1988) (PubMed).

    Terry, Brown, Beverley: "The monoclonal antibody, UCHL1, recognizes a 180,000 MW component of the human leucocyte-common antigen, CD45." in: Immunology, Vol. 64, Issue 2, pp. 331-6, (1988) (PubMed).

    Beverley: "Human T cell subsets." in: Immunology letters, Vol. 14, Issue 4, pp. 263-7, (1987) (PubMed).

    Norton, Ramsay, Smith, Beverley, Isaacson: "Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues." in: Journal of clinical pathology, Vol. 39, Issue 4, pp. 399-405, (1986) (PubMed).

    Smith, Brown, Rowe, Callard, Beverley: "Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1." in: Immunology, Vol. 58, Issue 1, pp. 63-70, (1986) (PubMed).

  • 抗原

    CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))

    别名

    CD45R0

    背景

    CD45R0 is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45R0 is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells.,PTPRCR, T200R0

    途径

    The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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