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STIM1 抗体 (C-Term)

This anti-STIM1 antibody is a 小鼠 单克隆 antibody detecting STIM1 in WB, IP, IHC (p) 和 ICC. Suitable for 人, 大鼠 和 小鼠. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN192394
发货至: 中国

Quick Overview for STIM1 抗体 (C-Term) (ABIN192394)

抗原

See all STIM1 抗体
STIM1 (Stromal Interaction Molecule 1 (STIM1))

适用

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人, 大鼠, 小鼠

宿主

  • 77
  • 6
  • 1
  • 1
小鼠

克隆类型

  • 67
  • 18
单克隆

标记

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This STIM1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

克隆位点

CDN3H4
  • 抗原表位

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    C-Term

    原理

    Anti-STIM1 Purified

    特异性

    The mouse monoclonal antibody CDN3H4 reacts with a cytoplasmic epitope of human and rodent STIM1, a 84 kDa essential and conserved regulator of store-operated Ca2+ channel function.

    交叉反应 (详细)

    Human, Mouse, Rat

    纯化方法

    Purified by protein-A affinity chromatography.

    纯度

    > 95 % (by SDS-PAGE)

    免疫原

    Synthetized peptide (C-terminal cytoplasmic part of STIM1).

    亚型

    IgG1
  • 应用备注

    Immunocytochemistry: Methanol-aceton fixation, positive control: HeLa human cervix carcinoma cell line.
    Immunohistochemistry (paraffin sections): Recommended dilution: 5 μg/mL.
    Western blotting: Recommended dilution: 1 μg/mL, positive control: RBL rat basophilic leukemia cell line, both reducing and non-reducing conditions.

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Do not freeze.
  • Hájková, Bugajev, Dráberová, Vinopal, Dráberová, Janá?ek, Dráber, Dráber: "STIM1-directed reorganization of microtubules in activated mast cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 2, pp. 913-23, (2011) (PubMed).

    Ng, Ramduny, Airey, Singer, Keller, Shen, Tian, Valencik, Hume: "Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells." in: American journal of physiology. Cell physiology, Vol. 299, Issue 5, pp. C1079-90, (2010) (PubMed).

  • 抗原

    STIM1 (Stromal Interaction Molecule 1 (STIM1))

    别名

    STIM1

    背景

    Stromal interaction molecule 1,STIM1 (stromal interacting molecule, also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.,GOK, TAM1, STRMK

    基因ID

    6786

    UniProt

    G0XQ39

    途径

    TCR Signaling, BCR Signaling
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