Myeloperoxidase 抗体
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北京 101111
Quick Overview for Myeloperoxidase 抗体 (ABIN191712)
抗原
See all Myeloperoxidase (MPO) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Protein G Chromatography
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免疫原
- Human Myeloperoxidase
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应用备注
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ELISA. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore in aqua bidest to 1 mg/mL.
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缓冲液
- TRIS, pH 7.4
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store lyophilized at 2-8 °C and reconstituted at -20 °C.
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- Myeloperoxidase (MPO)
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别名
- Myeloperoxidase
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背景
- Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59 - 64 kDa) and two unglycosylated beta chains (MW 14 kDa) with total MW 150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.Synonyms: MPO
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基因ID
- 9606
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UniProt
- P05164
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途径
- Chromatin Binding
抗原
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