FLIP 抗体 (AA 449-465)
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Quick Overview for FLIP 抗体 (AA 449-465) (ABIN1886881)
抗原
See all FLIP (CFLAR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 449-465
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特异性
- FLIP has short form (FLIPS) and long form (FLIPL) and antibody recognizes the FLIPL only.
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纯化方法
- Purified by DEAE column
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免疫原
- Peptide corresponding to amino acids 449 to 465 of mouse FLIPL/CASHa.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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注意事项
- Avoid freezing and thawing repeatly.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
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别名
- FLIP
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背景
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Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain (DD) containing adapter molecules and members of the ICE/CED-3 protease family.Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family.FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP respectively.The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH, CLARP and MRIT.FLIP contains two death effector domains (DEDs) and a caspase-like domain.FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors CD95, DR3, TRAIL-R and TNFR1.
Synonyms: I-FLICE -
分子量
- 55 kDa
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NCBI登录号
- NP_997536
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途径
- Apoptosis, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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