GFRA2 抗体 (AA 377-391)
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Quick Overview for GFRA2 抗体 (AA 377-391) (ABIN1886875)
抗原
See all GFRA2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 377-391
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纯化方法
- Purified by DEAE column
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免疫原
- Peptide corresponding to amino acids 377 to 391 of human GFR alpha 2.The amino acid sequences of immunogenic peptide are identical to those of mouse and rat.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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注意事项
- Avoid freezing and thawing repeatly.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- GFRA2 (GDNF Family Receptor alpha 2 (GFRA2))
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别名
- GFR alpha 2
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背景
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Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play key roles in the control of vertebrate neuron survival and differentiation.Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRalpha, which is a cell surface receptor for NTN.The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently.NTNRalpha was also termed GDNFRbeta, Ret ligand 2 (RETL2) or TGFbeta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRalpha-2 recently.GFRalpha-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF.Thus, NTN, GFRalpha-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
Synonyms: GFRa-2, GDNFRb, GDNFRbeta -
分子量
- 52 kDa
抗原
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