RRM2B 抗体 (AA 2-17)
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北京 101111
Quick Overview for RRM2B 抗体 (AA 2-17) (ABIN1886848)
抗原
See all RRM2B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-17
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Synthetic peptide corresponding to amino acids 2 to 17 of human p53R2.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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注意事项
- Avoid freezing and thawing repeatly.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
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别名
- p53R2
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背景
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The p53 tumor-suppressor gene integrates numerous signals that control cell life and death.Several novel molecules involved in p53 signaling, including p53R2 , Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered.p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase.p53R2 is induced by the reagents, ultraviolet and gamma-irradiation that cause DNA damages.The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA.The isoform of the p53 family member p73 also induces p53R2 expression.p53R2 is an important target of p53 for tumor suppression.
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分子量
- 39 kDa
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途径
- p53 Pathway, Negative Regulation of intrinsic apoptotic Signaling
抗原
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