Neurturin 抗体 (AA 178-193)
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Quick Overview for Neurturin 抗体 (AA 178-193) (ABIN1886843)
抗原
See all Neurturin (NRTN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 178-193
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Peptide corresponding to amino acids 178 to 193 of human neurturin.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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注意事项
- Avoid freezing and thawing repeatly.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- Neurturin (NRTN)
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别名
- Neurturin
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背景
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Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation.A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin.Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha.The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently and termed GDNFRbeta, Ret ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRalpha-2 recently.NTN binds to and forms a complex with GFRalpha-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway.Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations.Neurturin and GDNF define a new family of neurotrophic factors.
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分子量
- 14 kDa
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NCBI登录号
- NP_004549
抗原
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