C5 抗体 (AA 1223-1421)
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北京 101111
Quick Overview for C5 抗体 (AA 1223-1421) (ABIN1885991)
抗原
See all C5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1223-1421
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1223 and 1421 of Human C5
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应用备注
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Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500 -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- Biohazard Informations: This product contains thimerosal which is hazardous.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- C5 (Complement Component 5 (C5))
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背景
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The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes.This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge.An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase.The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections.Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.[provided by RefSeq]
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分子量
- 188 kDa
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基因ID
- 727
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NCBI登录号
- NM_001735, NP_001726
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途径
- Complement System, Carbohydrate Homeostasis
抗原
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