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FLT4 抗体 (AA 1-439)

This anti-FLT4 antibody is a 小鼠 单克隆 antibody detecting FLT4 in WB, FACS 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 5+ publications.
产品编号 ABIN1882290
发货至: 中国

Quick Overview for FLT4 抗体 (AA 1-439) (ABIN1882290)

抗原

See all FLT4 抗体
FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

适用

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宿主

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小鼠

克隆类型

  • 79
  • 35
单克隆

标记

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This FLT4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

818CT12-1-1
  • 抗原表位

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    AA 1-439

    纯化方法

    This antibody is purified through a protein G column, followed by dialysis against PBS.

    免疫原

    Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody.

    亚型

    IgG2a
  • 应用备注

    WB: 1:2000. IHC-P: 1:25. IHC-P: 1:25. IHC-P: 1:25. FC: 1:25

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • Dai, Liu, Liu, Zhang, Wang, Jin, Qian, Wang, Zhao, Wu, Xiong, Chang, Sun, Yang, Hoffman, Liu: "Anti-metastatic Efficacy of Traditional Chinese Medicine (TCM) Ginsenoside Conjugated to a VEFGR-3 Antibody on Human Gastric Cancer in an Orthotopic Mouse Model." in: Anticancer research, Vol. 37, Issue 3, pp. 979-986, (2017) (PubMed).

    Irrthum, Karkkainen, Devriendt, Alitalo, Vikkula: "Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase." in: American journal of human genetics, Vol. 67, Issue 2, pp. 295-301, (2000) (PubMed).

    Galland, Karamysheva, Pebusque, Borg, Rottapel, Dubreuil, Rosnet, Birnbaum: "The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor." in: Oncogene, Vol. 8, Issue 5, pp. 1233-40, (1993) (PubMed).

    Pajusola, Aprelikova, Korhonen, Kaipainen, Pertovaara, Alitalo, Alitalo: "FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines." in: Cancer research, Vol. 52, Issue 20, pp. 5738-43, (1992) (PubMed).

    Galland, Karamysheva, Mattei, Rosnet, Marchetto, Birnbaum: "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene." in: Genomics, Vol. 13, Issue 2, pp. 475-8, (1992) (PubMed).

  • 抗原

    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

    别名

    VEGFR3

    背景

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

    分子量

    152757

    NCBI登录号

    NP_002011, NP_891555

    UniProt

    P35916

    途径

    RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
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