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FLT4 抗体 (AA 1-439)

Name: FLT4 抗体 (AA 1-439)
SKU: ABIN1882290
Availability: OutOfStock

FLT4 适用: 人 WB, FACS, IHC (p) 宿主: 小鼠 Monoclonal 818CT12-1-1 unconjugated

VEGFR3 Antibody (ABIN1882290 and ABIN2843609) western blot analysis in 293 and A549 cell line lysates (35 μg/lane). (FLT4 抗体 (AA 1-439))

Flow cytometric analysis of HUVEC cells using VEGFR3(green, Cat (ABIN1882290 and ABIN2843609)) compared to an isotype control of mouse IgG2a(blue). (FLT4 抗体 (AA 1-439))

FACS

Immunohistochemical analysis of paraffin-embedded H. (FLT4 抗体 (AA 1-439))

IHC (p)

Immunohistochemical analysis of paraffin-embedded R. (FLT4 抗体 (AA 1-439))

IHC (p)

5 images

(5 references)

产品编号 ABIN1882290

发货至: 中国

Datasheet as PDF

抗原 See all FLT4 抗体

FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
抗原表位
15

13

5

4

4

4

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-439
适用
72

43

15

9
人
宿主
64

17

7

2

1
小鼠
Compatible Secondaries
克隆类型
65

26
单克隆
标记
50

7

6

4

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This FLT4 antibody is un-conjugated
应用范围
42

36

28

25

13

12

12

9

9

6

5

5

2

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is purified through a protein G column, followed by dialysis against PBS.

免疫原

Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody.

克隆位点

818CT12-1-1

亚型

IgG2a

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FLT4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5B5 unconjugated

anti-Fms-Related Tyrosine Kinase 4 (FLT4) antibody
FLT4 适用: 人 IHC (p) 宿主: 小鼠 Monoclonal 8C1 unconjugated

anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 640-700) antibody
FLT4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 1112-1329) antibody
FLT4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 34-133) antibody
FLT4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E3 unconjugated

应用备注

WB: 1:2000. IHC-P: 1:25. IHC-P: 1:25. IHC-P: 1:25. FC: 1:25

限制

仅限研究用
状态

Liquid

缓冲液

Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Dai, Liu, Liu, Zhang, Wang, Jin, Qian, Wang, Zhao, Wu, Xiong, Chang, Sun, Yang, Hoffman, Liu: "Anti-metastatic Efficacy of Traditional Chinese Medicine (TCM) Ginsenoside Conjugated to a VEFGR-3 Antibody on Human Gastric Cancer in an Orthotopic Mouse Model." in: Anticancer research, Vol. 37, Issue 3, pp. 979-986, (2017) (PubMed).

Irrthum, Karkkainen, Devriendt, Alitalo, Vikkula: "Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase." in: American journal of human genetics, Vol. 67, Issue 2, pp. 295-301, (2000) (PubMed).

Galland, Karamysheva, Pebusque, Borg, Rottapel, Dubreuil, Rosnet, Birnbaum: "The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor." in: Oncogene, Vol. 8, Issue 5, pp. 1233-40, (1993) (PubMed).

Pajusola, Aprelikova, Korhonen, Kaipainen, Pertovaara, Alitalo, Alitalo: "FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines." in: Cancer research, Vol. 52, Issue 20, pp. 5738-43, (1992) (PubMed).

Galland, Karamysheva, Mattei, Rosnet, Marchetto, Birnbaum: "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene." in: Genomics, Vol. 13, Issue 2, pp. 475-8, (1992) (PubMed).
抗原

FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

别名

VEGFR3 (FLT4 产品)

背景

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

分子量

152757

NCBI登录号

NP_002011, NP_891555

UniProt

P35916

途径

RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling