STK3 抗体 (AA 228-252)
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- 抗原 See all STK3 抗体
- STK3 (serine/threonine Kinase 3 (STK3))
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抗原表位
- AA 228-252
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适用
- 人, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This STK3 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This DANRE stk3(36kDa subunit) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 228-252 amino acids from the Central region of DANRE stk3(36kDa subunit).
- 克隆位点
- RB47395
- Top Product
- Discover our top product STK3 Primary Antibody
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- STK3 (serine/threonine Kinase 3 (STK3))
- 别名
- stk3 (STK3 产品)
- 背景
- Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (By similarity).
- 分子量
- 56081
- UniProt
- Q7ZUQ3
- 途径
- Tube Formation
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