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ATG4C 抗体 (AA 167-196)

ATG4C 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB7497 unconjugated
产品编号 ABIN1882159
发货至: 中国
  • 抗原 See all ATG4C 抗体
    ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))
    抗原表位
    • 16
    • 15
    • 11
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 167-196
    适用
    • 66
    • 30
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 59
    • 11
    • 2
    • 1
    克隆类型
    • 63
    • 10
    多克隆
    标记
    • 30
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATG4C antibody is un-conjugated
    应用范围
    • 67
    • 29
    • 24
    • 23
    • 13
    • 13
    • 13
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This ATG4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the Central region of human ATG4C.
    克隆位点
    RB7497
    亚型
    Ig Fraction
    Top Product
    Discover our top product ATG4C Primary Antibody
  • 应用备注
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Li, Hou, Wang, Chen, Shao, Yin: "Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates." in: The Journal of biological chemistry, Vol. 286, Issue 9, pp. 7327-38, (2011) (PubMed).

    Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." in: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, (2004) (PubMed).

  • 抗原
    ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))
    别名
    ATG4C (ATG4C 产品)
    别名
    apg4c antibody, atg4cl antibody, zgc:86888 antibody, wu:fc56g07 antibody, APG4-C antibody, APG4C antibody, AUTL1 antibody, AUTL3 antibody, Apg4-C antibody, Apg4c antibody, Atg4cl antibody, Autl1 antibody, autophagy related 4C cysteine peptidase antibody, autophagy related 4C, cysteine peptidase antibody, cysteine protease ATG4C antibody, ATG4C antibody, atg4c antibody, Tsp_15996 antibody, Atg4c antibody
    背景
    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
    分子量
    52497
    NCBI登录号
    NP_116241, NP_835739
    UniProt
    Q96DT6
    途径
    Autophagy
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