我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

ATG4A 抗体 (AA 82-111)

Name: ATG4A 抗体 (AA 82-111)
SKU: ABIN1882158
Availability: OutOfStock

This anti-ATG4A antibody is a 兔多克隆 antibody detecting ATG4A in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 3+ publications.

Western blot analysis of anti-G4A Pab 1808b in HepG2 cell line lysate. (ATG4A 抗体 (AA 82-111))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (ATG4A 抗体 (AA 82-111))

IHC (p)

2 images

(3 references)

产品编号 ABIN1882158

发货至: 中国

Quick Overview for ATG4A 抗体 (AA 82-111) (ABIN1882158)

抗原

See all ATG4A 抗体

ATG4A (Autophagy related 4A Cysteine Peptidase (ATG4A))

适用

人

宿主

兔

克隆类型

多克隆

标记

This ATG4A antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB7553

Discover our top product ATG4A Primary Antibody

抗原表位
15

7

4

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 82-111

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This ATG4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-111 amino acids from human ATG4A.

亚型

Ig Fraction
anti-Autophagy related 4A Cysteine Peptidase (ATG4A) (AA 258-398) antibody
ATG4A 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 8C9C2 unconjugated

anti-Autophagy related 4A Cysteine Peptidase (ATG4A) (AA 258-398) antibody
ATG4A 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 8E8G2 unconjugated

anti-Autophagy related 4A Cysteine Peptidase (ATG4A) (AA 289-398) antibody
ATG4A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Autophagy related 4A Cysteine Peptidase (ATG4A) (AA 363-392) antibody
ATG4A 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB7555 unconjugated

anti-Autophagy related 4A Cysteine Peptidase (ATG4A) (AA 369-398), (C-Term) antibody
ATG4A 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

anti-Autophagy related 4A Cysteine Peptidase (ATG4A) (AA 51-150) antibody
ATG4A 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Autophagy related 4A Cysteine Peptidase (ATG4A) antibody
ATG4A 适用: 人 WB, IHC (p), IF, IF (cc) 宿主: 小鼠 Monoclonal 14C9 unconjugated

anti-Autophagy related 4A Cysteine Peptidase (ATG4A) (AA 1-214) antibody
ATG4A 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Autophagy related 4A Cysteine Peptidase (ATG4A) (N-Term) antibody
ATG4A 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Autophagy related 4A Cysteine Peptidase (ATG4A) (Internal Region) antibody
Verified ATG4A 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Guo, Zhou, Gao, Zhang, Wei, Hong, Chu, Duan, Zhang, Xu: "MicroRNA-144-3p inhibits autophagy activation and enhances Bacillus Calmette-Guérin infection by targeting ATG4a in RAW264.7 macrophage cells." in: PLoS ONE, Vol. 12, Issue 6, pp. e0179772, (2017) (PubMed).

Li, Hou, Wang, Chen, Shao, Yin: "Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates." in: The Journal of biological chemistry, Vol. 286, Issue 9, pp. 7327-38, (2011) (PubMed).

Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." in: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, (2004) (PubMed).
抗原

ATG4A (Autophagy related 4A Cysteine Peptidase (ATG4A))

别名

ATG4A

背景

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4A is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.

分子量

45378

NCBI登录号

NP_443168, NP_840054

UniProt

Q8WYN0

途径

Autophagy