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SUMO1 抗体 (N-Term)

Name: SUMO1 抗体 (N-Term)
SKU: ABIN1882136
Availability: OutOfStock

This anti-SUMO1 antibody is a 兔多克隆 antibody detecting SUMO1 in WB, IF, FACS 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 10+ publications.

The anti-SUMO1 polyclonal antibody (ABIN1882136 and ABIN2845486) is used in Western blot to detect SUMO1 in HL-60 cell lysate. (SUMO1 抗体 (N-Term))

SUMO1 Antibody (N-term) (ABIN1882136 and ABIN2845486) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram). (SUMO1 抗体 (N-Term))

FACS

Confocal immunofluorescent analysis of SUMO1 Antibody (N-term) (ABIN1882136 and ABIN2845486) with cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (SUMO1 抗体 (N-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (SUMO1 抗体 (N-Term))

IHC (p)

4 images

(10 references)

产品编号 ABIN1882136

发货至: 中国

Datasheet as PDF

Quick Overview for SUMO1 抗体 (N-Term) (ABIN1882136)

抗原

See all SUMO1 抗体

SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This SUMO1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB0629

Discover our top product SUMO1 Primary Antibody

抗原表位
15

15

10

9

8

6

4

3

3

1

1

1

1

1

1

1

1
AA 1-30, N-Term

预测反应

B, M, Pig, Rat

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This SUMO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SUMO1.

亚型

Ig Fraction
anti-Small Ubiquitin Related Modifier Protein 1 (SUMO1) antibody
SUMO1 适用: 人, 大鼠, 小鼠 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Small Ubiquitin Related Modifier Protein 1 (SUMO1) antibody
SUMO1 适用: 人 WB, IF, IHC 宿主: 兔 Monoclonal unconjugated

anti-Small Ubiquitin Related Modifier Protein 1 (SUMO1) (AA 1-101) antibody
SUMO1 适用: 人 WB, IF, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D7 unconjugated

anti-Small Ubiquitin Related Modifier Protein 1 (SUMO1) antibody
SUMO1 适用: 人, 大鼠 WB, IF, IHC, FACS, StM 宿主: 小鼠 Monoclonal SM1-495 unconjugated

anti-Small Ubiquitin Related Modifier Protein 1 (SUMO1) (N-Term) antibody
SUMO1 适用: 人, 大鼠, 小鼠 WB, IF, IHC, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

anti-Small Ubiquitin Related Modifier Protein 1 (SUMO1) (AA 1-101) antibody
SUMO1 适用: 人 WB, IF, IHC, IP 宿主: 兔 Polyclonal unconjugated

anti-Small Ubiquitin Related Modifier Protein 1 (SUMO1) (AA 55-86) antibody
SUMO1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Small Ubiquitin Related Modifier Protein 1 (SUMO1) (AA 52-79) antibody
SUMO1 适用: 人 WB, IF, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Small Ubiquitin Related Modifier Protein 1 (SUMO1) (AA 1-30) antibody
SUMO1 适用: 人 WB, IF, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Small Ubiquitin Related Modifier Protein 1 (SUMO1) antibody
SUMO1 适用: 人 IHC, ELISA, FACS, IP 宿主: 兔 Monoclonal 5G3 unconjugated Recombinant Antibody

应用备注

IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Saito, Souza, Costa, Meirelles, Gonçalves, Santos, Bressan, McComb, Costello, Whelan, Kobarg: "Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation." in: Journal of proteome research, Vol. 16, Issue 9, pp. 3147-3157, (2018) (PubMed).

Janer, Werner, Takahashi-Fujigasaki, Daret, Fujigasaki, Takada, Duyckaerts, Brice, Dejean, Sittler: "SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7." in: Human molecular genetics, Vol. 19, Issue 1, pp. 181-95, (2009) (PubMed).

Ji, Degerny, Vintonenko, Deheuninck, Foveau, Leroy, Coll, Tulasne, Baert, Fafeur: "Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation." in: Oncogene, Vol. 26, Issue 3, pp. 395-406, (2007) (PubMed).

Bradley, van der Meer, Roodi, Yan, Chandrasekharan, Sun, Mernaugh, Parl: "Carcinogen-induced histone alteration in normal human mammary epithelial cells." in: Carcinogenesis, Vol. 28, Issue 10, pp. 2184-92, (2007) (PubMed).

Degerny, Monte, Beaudoin, Jaffray, Portois, Hay, de Launoit, Baert: "SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity." in: The Journal of biological chemistry, Vol. 280, Issue 26, pp. 24330-8, (2005) (PubMed).

Yang, Sharrocks: "SUMO promotes HDAC-mediated transcriptional repression." in: Molecular cell, Vol. 13, Issue 4, pp. 611-7, (2004) (PubMed).

Ling, Sankpal, Robertson, McNally, Karpova, Robertson: "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription." in: Nucleic acids research, Vol. 32, Issue 2, pp. 598-610, (2004) (PubMed).

Bailey, OHare: "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 692-703, (2003) (PubMed).

Pountney, Huang, Burns, Haan, Thompson, Blumbergs, Gai: "SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease." in: Experimental neurology, Vol. 184, Issue 1, pp. 436-46, (2003) (PubMed).

Ohshima, Shimotohno: "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 50833-42, (2003) (PubMed).
抗原

SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

别名

SUMO1

背景

Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT3B, TDG, HIF1A, CHD3, EXOSC9, RAD51, and viral targets such as CMV-IE1/2, EBV-BZLF1, and HPV/BPV-E1.

分子量

11557

NCBI登录号

NP_001005781, NP_001005782, NP_003343

UniProt

P63165

途径

M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway