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SDHB 抗体 (C-Term)

This anti-SDHB antibody is a 兔 多克隆 antibody detecting SDHB in WB. Suitable for 人. This Primary Antibody has been cited in 6+ publications.
产品编号 ABIN1881781
发货至: 中国

Quick Overview for SDHB 抗体 (C-Term) (ABIN1881781)

抗原

See all SDHB 抗体
SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))

适用

  • 90
  • 41
  • 26
  • 6
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1

宿主

  • 78
  • 16
  • 2

克隆类型

  • 64
  • 32
多克隆

标记

  • 51
  • 6
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This SDHB antibody is un-conjugated

应用范围

  • 66
  • 26
  • 22
  • 21
  • 13
  • 13
  • 10
  • 9
  • 8
  • 8
  • 3
  • 2
  • 1
Western Blotting (WB)

克隆位点

RB41925
  • 抗原表位

    • 16
    • 13
    • 9
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 205-234, C-Term

    预测反应

    B, M, Pig

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This SDHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the C-terminal region of human SDHB.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • Ho, Morrison, Silva, Coomber: "The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression." in: Bioscience reports, Vol. 36, Issue 1, pp. e00299, (2016) (PubMed).

    Boominathan, Vanhoozer, Basisty, Powers, Crampton, Wang, Friedricks, Schilling, Brand, OConnor: "Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant." in: Nucleic acids research, Vol. 44, Issue 19, pp. 9342-9357, (2016) (PubMed).

    Cerecer-Gil, Figuera, Llamas, Lara, Escamilla, Ramos, Estrada, Hussain, Gaal, Korpershoek, de Krijger, Dinjens, Devilee, Bayley: "Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 16, pp. 4148-54, (2010) (PubMed).

    Hes, Weiss, Woortman, de Miranda, van Bunderen, Bonsing, Stokkel, Morreau, Romijn, Jansen, Vriends, Bayley, Corssmit: "Low penetrance of a SDHB mutation in a large Dutch paraganglioma family." in: BMC medical genetics, Vol. 11, pp. 92, (2010) (PubMed).

    Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).

    Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

  • 抗原

    SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))

    别名

    SDHB

    背景

    Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

    分子量

    31630

    NCBI登录号

    NP_002991

    UniProt

    P21912
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