PROX1 抗体 (AA 175-206)
(4 references)Quick Overview for PROX1 抗体 (AA 175-206) (ABIN1881686)
抗原
See all PROX1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 175-206
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预测反应
- M
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This PROX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-206 amino acids from human PROX1.
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亚型
- Ig Fraction
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anti-Prospero Homeobox 1 (PROX1) (AA 638-737) antibody
PROX1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H6 unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 492-522) antibodyPROX1 适用: 人, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 492-520) antibodyPROX1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 185-214) antibodyPROX1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 638-737) antibodyPROX1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E7 unconjugated
anti-Prospero Homeobox 1 (PROX1) (Center) antibodyPROX1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 444-478) antibodyPROX1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51404 unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 1-300) antibodyPROX1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) (AA 547-737) antibodyPROX1 适用: 人, 马, Avian WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prospero Homeobox 1 (PROX1) antibodyPROX1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies." in: Genes, chromosomes & cancer, Vol. 38, Issue 1, pp. 13-21, (2003) (PubMed).
: "Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 225, Issue 3, pp. 351-7, (2002) (PubMed).
: "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor." in: The EMBO journal, Vol. 21, Issue 17, pp. 4593-9, (2002) (PubMed).
: "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis." in: Cancer research, Vol. 61, Issue 22, pp. 8079-84, (2001) (PubMed).
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: "Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies." in: Genes, chromosomes & cancer, Vol. 38, Issue 1, pp. 13-21, (2003) (PubMed).
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- PROX1 (Prospero Homeobox 1 (PROX1))
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别名
- PROX1
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背景
- The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been documented to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.
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分子量
- 83203
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NCBI登录号
- NP_001257545, NP_002754
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UniProt
- Q92786
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途径
- Stem Cell Maintenance, Regulation of Muscle Cell Differentiation
抗原
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