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PARK7/DJ1 抗体 (C-Term)

Name: PARK7/DJ1 抗体 (C-Term)
SKU: ABIN1881625
Availability: OutOfStock

PARK7 适用: 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated

DANRE park7 Antibody (C-term) Azb10028b western blot analysis in zebra fish brain and muscle tissue lysates (35 μg/lane). (PARK7/DJ1 抗体 (C-Term))

1 image

(2 references)

产品编号 ABIN1881625

发货至: 中国

Datasheet as PDF

抗原 See all PARK7/DJ1 (PARK7) 抗体

PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
抗原表位
21

16

10

7

5

5

4

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 120-149, C-Term
适用
94

71

51

8

5

4

3

3

2

2

1

1

1

1

1
斑马鱼
宿主
99

15

2

1
兔
Compatible Secondaries
克隆类型
93

24
多克隆
标记
71

13

9

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1
This PARK7/DJ1 antibody is un-conjugated
应用范围
97

44

31

31

27

21

20

15

14

13

5

5

5

4

2

1

1

1
Western Blotting (WB)

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This DANRE park7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the C-terminal region of DANRE park7.

亚型

Ig Fraction

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anti-Parkinson Protein 7 (PARK7) (AA 2-189) antibody
PARK7 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 7 (PARK7) (AA 1-189) antibody
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PARK7 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

应用备注

WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Bretaud, Allen, Ingham, Bandmann: "p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease." in: Journal of neurochemistry, Vol. 100, Issue 6, pp. 1626-35, (2007) (PubMed).

Bai, Mullett, Garver, Hinkle, Burton: "Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons." in: Brain research, Vol. 1113, Issue 1, pp. 33-44, (2006) (PubMed).
抗原

PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

别名

park7 (PARK7 产品)

别名

DJ-1 antibody, DJ1 antibody, CAP1 antibody, Dj1 antibody, SP22 antibody, dj1 antibody, zgc:103725 antibody, park7b antibody, park7 antibody, park7a antibody, Parkinsonism associated deglycase antibody, Parkinson disease (autosomal recessive, early onset) 7 antibody, parkinson protein 7 antibody, parkinson protein 7 S homeolog antibody, parkinson protein 7 L homeolog antibody, PARK7 antibody, Park7 antibody, park7 antibody, park7.S antibody, park7.L antibody

背景

Protects cells against oxidative stress and cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone (By similarity). Protects dopaminergic neurons against cell death arising from oxidative stress and proteasome inhibition, probably by a TP53/p53-dependent mechanism.

分子量

19764

NCBI登录号

NP_001005938

UniProt

Q5XJ36

途径

Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport