PARK7/DJ1 抗体 (C-Term)
(2 references)Quick Overview for PARK7/DJ1 抗体 (C-Term) (ABIN1881625)
抗原
See all PARK7/DJ1 (PARK7) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 120-149, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This DANRE park7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the C-terminal region of DANRE park7.
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亚型
- Ig Fraction
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anti-Parkinson Protein 7 (PARK7) (AA 1-189) antibody
PARK7 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (C-Term) antibodyVerified PARK7 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 101-189) antibodyPARK7 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (C-Term) antibodyPARK7 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 2-189) antibodyPARK7 适用: 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 1-188) antibodyPARK7 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 1-189) antibodyPARK7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 2-189) antibodyPARK7 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 1-189) antibodyPARK7 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Parkinson Protein 7 (PARK7) (AA 130-164), (C-Term) antibodyPARK7 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB49681 unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease." in: Journal of neurochemistry, Vol. 100, Issue 6, pp. 1626-35, (2007) (PubMed).
: "Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons." in: Brain research, Vol. 1113, Issue 1, pp. 33-44, (2006) (PubMed).
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: "p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease." in: Journal of neurochemistry, Vol. 100, Issue 6, pp. 1626-35, (2007) (PubMed).
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- PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
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别名
- park7
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背景
- Protects cells against oxidative stress and cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone (By similarity). Protects dopaminergic neurons against cell death arising from oxidative stress and proteasome inhibition, probably by a TP53/p53-dependent mechanism.
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分子量
- 19764
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NCBI登录号
- NP_001005938
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UniProt
- Q5XJ36
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport
抗原
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