电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

IRF3 抗体 (N-Term)

IRF3 适用: 小鼠 WB 宿主: 兔 Polyclonal RB42372 unconjugated
产品编号 ABIN1881465
发货至: 中国
  • 抗原 See all IRF3 抗体
    IRF3 (Interferon Regulatory Factor 3 (IRF3))
    抗原表位
    • 17
    • 15
    • 15
    • 13
    • 13
    • 9
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 46-72, N-Term
    适用
    • 140
    • 90
    • 56
    • 31
    • 18
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    小鼠
    宿主
    • 150
    • 12
    • 2
    克隆类型
    • 135
    • 29
    多克隆
    标记
    • 85
    • 12
    • 9
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This IRF3 antibody is un-conjugated
    应用范围
    • 118
    • 67
    • 32
    • 29
    • 29
    • 27
    • 19
    • 9
    • 8
    • 7
    • 6
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    预测反应
    B, Pig
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.
    克隆位点
    RB42372
    亚型
    Ig Fraction
    Top Product
    Discover our top product IRF3 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Marichal, Bedoret, Mesnil, Pichavant, Goriely, Trottein, Cataldo, Goldman, Lekeux, Bureau, Desmet: "Interferon response factor 3 is essential for house dust mite-induced airway allergy." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 4, pp. 836-844.e13, (2010) (PubMed).

    Menachery, Pasieka, Leib: "Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection." in: Journal of virology, Vol. 84, Issue 19, pp. 9685-94, (2010) (PubMed).

    Carrigan, Junkins, Yang, Macneil, Richardson, Johnston, Lin: "IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 6, pp. 3602-9, (2010) (PubMed).

    Wang, Basagoudanavar, Wang, Hopewell, Albrecht, García-Sastre, Balachandran, Beg: "NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1720-9, (2010) (PubMed).

    Farlik, Reutterer, Schindler, Greten, Vogl, Müller, Decker: "Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression." in: Immunity, Vol. 33, Issue 1, pp. 25-34, (2010) (PubMed).

  • 抗原
    IRF3 (Interferon Regulatory Factor 3 (IRF3))
    别名
    Irf3 (IRF3 产品)
    别名
    irf3 antibody, IRF3 antibody, C920001K05Rik antibody, IRF-3 antibody, interferon regulatory factor 3 antibody, interferon regulatory factor 7 antibody, irf3 antibody, IRF3 antibody, irf-3 antibody, Irf3 antibody, IRF7 antibody
    背景
    Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).
    分子量
    46852
    NCBI登录号
    NP_058545
    UniProt
    P70671
    途径
    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
You are here:
客服