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- 抗原 See all IRF3 抗体
- IRF3 (Interferon Regulatory Factor 3 (IRF3))
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抗原表位
- AA 46-72, N-Term
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IRF3 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- B, Pig
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.
- 克隆位点
- RB42372
- 亚型
- Ig Fraction
- Top Product
- Discover our top product IRF3 Primary Antibody
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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Interferon response factor 3 is essential for house dust mite-induced airway allergy." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 4, pp. 836-844.e13, (2010) (PubMed).
: "Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection." in: Journal of virology, Vol. 84, Issue 19, pp. 9685-94, (2010) (PubMed).
: "IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 6, pp. 3602-9, (2010) (PubMed).
: "NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1720-9, (2010) (PubMed).
: "Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression." in: Immunity, Vol. 33, Issue 1, pp. 25-34, (2010) (PubMed).
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Interferon response factor 3 is essential for house dust mite-induced airway allergy." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 4, pp. 836-844.e13, (2010) (PubMed).
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- 抗原
- IRF3 (Interferon Regulatory Factor 3 (IRF3))
- 别名
- Irf3 (IRF3 产品)
- 别名
- irf3 antibody, IRF3 antibody, C920001K05Rik antibody, IRF-3 antibody, interferon regulatory factor 3 antibody, interferon regulatory factor 7 antibody, irf3 antibody, IRF3 antibody, irf-3 antibody, Irf3 antibody, IRF7 antibody
- 背景
- Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).
- 分子量
- 46852
- NCBI登录号
- NP_058545
- UniProt
- P70671
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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