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IRF3 抗体 (N-Term)

Cited in 5+ publications. The 兔多克隆 anti-IRF3 antibody (Clone RB42372) (ABIN1881465) specifically detects IRF3 in WB. The antibody is reactive with 小鼠 samples.

1 image

(5 references)

产品编号 ABIN1881465

发货至: 中国

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Quick Overview for IRF3 抗体 (N-Term) (ABIN1881465)

抗原

See all IRF3 抗体

IRF3 (Interferon Regulatory Factor 3 (IRF3))

适用

小鼠

宿主

兔

克隆类型

多克隆

标记

This IRF3 antibody is un-conjugated

应用范围

Western Blotting (WB)

克隆位点

RB42372

Discover our top product IRF3 Primary Antibody

抗原表位
27

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9

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2

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1
AA 46-72, N-Term

预测反应

B, Pig

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.

亚型

Ig Fraction
anti-Interferon Regulatory Factor 3 (IRF3) (pSer396) antibody
IRF3 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-260) antibody
IRF3 适用: 人 WB, IHC, IF, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibody
IRF3 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 3C8 unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 51-150) antibody
IRF3 适用: 人, 小鼠, 大鼠, 猴, Cow WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-360) antibody
IRF3 适用: 人 WB, IHC, ICC, IP, FACS 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (pSer386) antibody
IRF3 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (C-Term) antibody
IRF3 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) antibody
IRF3 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 4C3 unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) antibody
IRF3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibody
IRF3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Marichal, Bedoret, Mesnil, Pichavant, Goriely, Trottein, Cataldo, Goldman, Lekeux, Bureau, Desmet: "Interferon response factor 3 is essential for house dust mite-induced airway allergy." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 4, pp. 836-844.e13, (2010) (PubMed).

Menachery, Pasieka, Leib: "Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection." in: Journal of virology, Vol. 84, Issue 19, pp. 9685-94, (2010) (PubMed).

Carrigan, Junkins, Yang, Macneil, Richardson, Johnston, Lin: "IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 6, pp. 3602-9, (2010) (PubMed).

Wang, Basagoudanavar, Wang, Hopewell, Albrecht, García-Sastre, Balachandran, Beg: "NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1720-9, (2010) (PubMed).

Farlik, Reutterer, Schindler, Greten, Vogl, Müller, Decker: "Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression." in: Immunity, Vol. 33, Issue 1, pp. 25-34, (2010) (PubMed).
抗原

IRF3 (Interferon Regulatory Factor 3 (IRF3))

别名

Irf3

背景

Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).

分子量

46852

NCBI登录号

NP_058545

UniProt

P70671

途径

TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades