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ErbB2/Her2 抗体 (pTyr1112)

Name: ErbB2/Her2 抗体 (pTyr1112)
SKU: ABIN1881304
Availability: OutOfStock

This anti-ErbB2/Her2 antibody is a 兔多克隆 antibody detecting ErbB2/Her2 in WB 和 DB. Suitable for 人. This Primary Antibody has been cited in 5+ publications.

Western blot analysis of extracts from A431 cells, untreated or treated with EGF at 100 ng/mL, using phospho-ErBB2 (left) or ErBB2 antibody (right). (ErbB2/Her2 抗体 (pTyr1112))

Dot blot analysis of Phospho-ERBB2- Phospho-specific Pab (ABIN1881304 and ABIN2850444) on nitrocellulose membrane. (ErbB2/Her2 抗体 (pTyr1112))

2 images

(5 references)

产品编号 ABIN1881304

发货至: 中国

Quick Overview for ErbB2/Her2 抗体 (pTyr1112) (ABIN1881304)

抗原

See all ErbB2/Her2 抗体

ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

适用

人

宿主

兔

克隆类型

多克隆

标记

This ErbB2/Her2 antibody is un-conjugated

应用范围

Western Blotting (WB), Dot Blot (DB)

克隆位点

RB40063

Discover our top product ErbB2/Her2 Primary Antibody

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pTyr1112

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This ErbB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1112 of human ErbB2.

亚型

Ig Fraction
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-372) antibody
ErbB2/Her2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) antibody
ErbB2/Her2 适用: 人, 小鼠, 大鼠, 犬, 猴, 马, Pig, 兔, Cow, Hamster, Avian, Cat, 小鸡, 驴, 山羊, 豚鼠, 绵羊 WB 宿主: 山羊 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 22-121) antibody
ErbB2/Her2 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 3B1 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr1248) antibody
ErbB2/Her2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr1112) antibody
ErbB2/Her2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr877) antibody
ErbB2/Her2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) antibody
ErbB2/Her2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 311-462) antibody
ErbB2/Her2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ERBB2-3078 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 311-462) antibody
ErbB2/Her2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ERBB2-2452 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 22-121) antibody
ErbB2/Her2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4E1 unconjugated

应用备注

WB: 1:2000. DB: 1:500

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Mándoky, Géczi, Bodrogi, Tóth, Csuka, Kásler, Bak: "Clinical relevance of HER-2/neu expression in germ-cell testicular tumors." in: Anticancer research, Vol. 24, Issue 4, pp. 2219-24, (2004) (PubMed).

Contreras, Cobos, Lox: "Is the circulating urokinase plasminogen activator upregulated by the circulating p105 fraction of the HER-2/neu proto-oncogene in patients with cervical cancer?" in: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, Vol. 10, Issue 3, pp. 271-6, (2004) (PubMed).

Stephens, Hunter, Bignell, Edkins, Davies, Teague, Stevens, OMeara, Smith, Parker, Barthorpe, Blow, Brackenbury, Butler, Clarke, Cole, Dicks, Dike, Drozd, Edwards, Forbes, Foster, Gray, Greenman et al.: "Lung cancer: intragenic ERBB2 kinase mutations in tumours. ..." in: Nature, Vol. 431, Issue 7008, pp. 525-6, (2004) (PubMed).

Wang, Lien, Xia, Chen, Lo, Wang, Ali-Seyed, Lee, Bartholomeusz, Ou-Yang, Giri, Hung: "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2." in: Cancer cell, Vol. 6, Issue 3, pp. 251-61, (2004) (PubMed).

Menendez, Vellon, Mehmi, Oza, Ropero, Colomer, Lupu: "Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10715-20, (2004) (PubMed).
抗原

ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

别名

ERBB2

背景

ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.

分子量

137910

NCBI登录号

NP_001005862, NP_004439

UniProt

P04626

途径

RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development