CDK2 抗体 (AA 1-30)
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- 抗原 See all CDK2 抗体
- CDK2 (Cyclin-Dependent Kinase 2 (CDK2))
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抗原表位
- AA 1-30
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CDK2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 预测反应
- B, Ha, M, Rat, X
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This CDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human CDK2.
- 克隆位点
- RB7918
- 亚型
- Ig Fraction
- Top Product
- Discover our top product CDK2 Primary Antibody
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- 应用备注
- WB: 1:1000. IHC-P: 1:10~50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 1026-31, (2003) (PubMed).
: "Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 40815-28, (2003) (PubMed).
: "Epstein-Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2." in: Oncogene, Vol. 22, Issue 46, pp. 7181-91, (2003) (PubMed).
: "Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36966-72, (2003) (PubMed).
: "Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest." in: Journal of virology, Vol. 77, Issue 17, pp. 9652-61, (2003) (PubMed).
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SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 1026-31, (2003) (PubMed).
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- 抗原
- CDK2 (Cyclin-Dependent Kinase 2 (CDK2))
- 别名
- CDK2 (CDK2 产品)
- 别名
- p33(CDK2) antibody, A630093N05Rik antibody, wu:fa10c02 antibody, zgc:56598 antibody, zgc:77684 antibody, eg1 antibody, CDKN2 antibody, cdk2L antibody, cyclin dependent kinase 2 antibody, cyclin-dependent kinase 2 antibody, cyclin-dependent kinase 2 S homeolog antibody, CDK2 antibody, Cdk2 antibody, cdk2 antibody, cdk2.S antibody
- 背景
- CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation.
- 分子量
- 33930
- NCBI登录号
- NP_001789, NP_439892
- UniProt
- P24941
- 途径
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
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