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CD46 抗体 (AA 330-361)

This anti-CD46 antibody is a 兔 多克隆 antibody detecting CD46 in WB. Suitable for 人. This Primary Antibody has been cited in 5+ publications.
产品编号 ABIN1881186
发货至: 中国

Quick Overview for CD46 抗体 (AA 330-361) (ABIN1881186)

抗原

See all CD46 抗体
CD46

适用

  • 130
  • 37
  • 23
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  • 3

宿主

  • 90
  • 63
  • 2
  • 1

克隆类型

  • 79
  • 77
多克隆

标记

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  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CD46 antibody is un-conjugated

应用范围

  • 92
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  • 22
  • 14
  • 14
  • 9
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  • 5
  • 5
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • 抗原表位

    • 16
    • 10
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    • 2
    • 2
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    • 1
    • 1
    • 1
    AA 330-361

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This CD46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • Riley, Kemper, Leung, Atkinson: "Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa." in: Molecular reproduction and development, Vol. 62, Issue 4, pp. 534-46, (2002) (PubMed).

    Cervoni, Fenichel, Akhoundi, Hsi, Rossi: "Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46)." in: Molecular reproduction and development, Vol. 34, Issue 1, pp. 107-13, (1993) (PubMed).

    Post, Liszewski, Adams, Tedja, Miller, Atkinson: "Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype." in: The Journal of experimental medicine, Vol. 174, Issue 1, pp. 93-102, (1991) (PubMed).

    Purcell, Russell, Deacon, Brown, Hooker, McKenzie: "Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation." in: Immunogenetics, Vol. 33, Issue 5-6, pp. 335-44, (1991) (PubMed).

    Lublin, Liszewski, Post, Arce, Le Beau, Rebentisch, Lemons, Seya, Atkinson: "Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins." in: The Journal of experimental medicine, Vol. 168, Issue 1, pp. 181-94, (1988) (PubMed).

  • 抗原

    CD46

    别名

    CD46

    背景

    Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

    分子量

    43747

    NCBI登录号

    NP_002380, NP_722548, NP_758860, NP_758861, NP_758862, NP_758863, NP_758869, NP_758871

    UniProt

    P15529

    途径

    Regulation of Actin Filament Polymerization
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