CD46 抗体 (AA 330-361)
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北京 101111
Quick Overview for CD46 抗体 (AA 330-361) (ABIN1881186)
抗原
See all CD46 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 330-361
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This CD46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46.
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亚型
- Ig Fraction
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anti-CD46 (CD46) (AA 40-320) antibody
CD46 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD46 (CD46) (AA 35-179) antibodyCD46 适用: 人 WB, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 5A8C11 unconjugated
anti-CD46 (CD46) (AA 35-179) antibodyCD46 适用: 人 FACS, IHC, ELISA 宿主: 小鼠 Monoclonal 1A5A5 unconjugated
anti-CD46 (CD46) antibodyKD Validated CD46 适用: 人 WB, FACS, ICC, IF (p) 宿主: 兔 Monoclonal 23GB5720 unconjugated Recombinant Antibody
anti-CD46 (CD46) (AA 317-343) antibodyCD46 适用: 人 WB, FACS, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD46 (CD46) (AA 251-355) antibodyCD46 适用: 人, 小鼠 WB, FACS, ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-CD46 (CD46) antibodyCD46 适用: 人, Cow WB, FACS, IP 宿主: 小鼠 Monoclonal MEM-258 unconjugated
anti-CD46 (CD46) antibodyCD46 适用: 人, Cow WB, FACS, IP 宿主: 小鼠 Monoclonal MEM-258 unconjugated
anti-CD46 (CD46) antibodyCD46 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal 7D12 unconjugated Recombinant Antibody
anti-CD46 (CD46) antibody (Biotin)CD46 适用: 人, Cow WB, FACS, IP 宿主: 小鼠 Monoclonal MEM-258 Biotin
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa." in: Molecular reproduction and development, Vol. 62, Issue 4, pp. 534-46, (2002) (PubMed).
: "Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46)." in: Molecular reproduction and development, Vol. 34, Issue 1, pp. 107-13, (1993) (PubMed).
: "Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype." in: The Journal of experimental medicine, Vol. 174, Issue 1, pp. 93-102, (1991) (PubMed).
: "Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation." in: Immunogenetics, Vol. 33, Issue 5-6, pp. 335-44, (1991) (PubMed).
: "Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins." in: The Journal of experimental medicine, Vol. 168, Issue 1, pp. 181-94, (1988) (PubMed).
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: "Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa." in: Molecular reproduction and development, Vol. 62, Issue 4, pp. 534-46, (2002) (PubMed).
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- CD46
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别名
- CD46
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背景
- Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
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分子量
- 43747
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NCBI登录号
- NP_002380, NP_722548, NP_758860, NP_758861, NP_758862, NP_758863, NP_758869, NP_758871
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UniProt
- P15529
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途径
- Regulation of Actin Filament Polymerization
抗原
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