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TLR3 抗体

TLR3 适用: 人, 小鼠 WB, FACS, IP, IF, IHC (p) 宿主: 小鼠 Monoclonal 40C1285-6 unconjugated
产品编号 ABIN187555
发货至: 中国
  • 抗原 See all TLR3 抗体
    TLR3 (Toll-Like Receptor 3 (TLR3))
    适用
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    人, 小鼠
    宿主
    • 84
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    小鼠
    克隆类型
    • 87
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    单克隆
    标记
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    This TLR3 antibody is un-conjugated
    应用范围
    • 80
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    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    Recognizes human Toll-like Receptor 3 (TLR3). Species Reactivity: Human and mouse. Others not tested.
    免疫原
    Synthetic peptides derived from the cytoplasmic portion of human TLR3.
    克隆位点
    40C1285-6
    亚型
    IgG1
    Top Product
    Discover our top product TLR3 Primary Antibody
  • 应用备注
    Flow cytometry: Use 2-5 µg/106 cells for intracellular staining. Immunoprecipitation: Use 2 µg/106 transfected cells. Western blot: Use at 1-3 µg/mL. Immunohistochemistry: (paraffin sections) Immunocytochemistry The optimal dilution for a specific application should be determined by the researcher.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    100 µg of liquid Protein G purified monoclonal antibody at 0.5 mg/mL in PBS containing protein stabilizer and 0.05% sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • 抗原
    TLR3 (Toll-Like Receptor 3 (TLR3))
    别名
    CD283 / TLR3 (TLR3 产品)
    别名
    CD283 antibody, IIAE2 antibody, AI957183 antibody, zgc:123006 antibody, toll like receptor 3 antibody, toll-like receptor 3 antibody, TLR3 antibody, Tlr3 antibody, tlr3 antibody
    背景
    The Toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. TLR3 cDNA codes for a protein, ~120 kDa. TLR3 has a restricted expression pattern being expressed in dendritic cells (DC). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes. The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.
    途径
    TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
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