TRAIL 抗体
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北京 101111
Quick Overview for TRAIL 抗体 (ABIN187524)
抗原
See all TRAIL (TNFSF10) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes human TRAIL Species Reactivity: Human.
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免疫原
- Recombinant human soluble TRAIL (Apo-2L)
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亚型
- IgG2b
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应用备注
- Western blotting Flow Cytometry Immunohistochemistry: Frozen sections Immunoprecipitation ELISA The optimal dilution for a specific application should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 100 µl of purified antibody in PBS containing 0.02% NaN3. Concentration 1 mg/ml IgG.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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- TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
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别名
- CD253 / TRAIL
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背景
- Tumor necrosis factor (TNF-)-related apoptosis-inducing ligand (TRAIL, APO-2L) is thought to regulate cell death events in the immune system through TRAIL-R1 (DR4) and TRAIL-R2 (DR5), members of the TNF receptor superfamily. Like the death receptors, including Fas and TNF-R, TRAIL-R1 and TRAIL-R2 have death domains in their cytoplasmic tails that recruit proteins to initiate a cell death signaling cascade. TRAIL (APO-2L) is a 34 kDa type II transmembrane protein. TRAIL forms trimers and is a member of the TNF ligand family. Interaction between TRAIL and TRAIL-R1 and/or TRAIL-R2 rapidly induces apoptosis of TRAIL-sensitive cells. TRAIL can be injected into mice without toxic side effects. Many tumor cells are killed by TRAIL and TRAIL is currently being considered as on of the most promising potential new cancer therapeutics.
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途径
- Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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