TLR9 抗体
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北京 101111
Quick Overview for TLR9 抗体 (ABIN187334)
抗原
See all TLR9 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Reacts with mouse TLR9. Weak cross-reactivity with human TLR9. Species Reactivity: Mouse and human. Others not tested.
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过滤
- 0.2 μm filtered
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亚型
- IgG2a
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anti-Toll-Like Receptor 9 (TLR9) (AA 868-1016) antibody
TLR9 适用: 人 IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 1B12H2 unconjugated
anti-Toll-Like Receptor 9 (TLR9) (AA 28-362) antibodyTLR9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 9 (TLR9) (AA 350-450) antibodyTLR9 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 9 (TLR9) (AA 26-193) antibodyTLR9 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5B10E8 unconjugated
anti-Toll-Like Receptor 9 (TLR9) (AA 951-1032) antibodyTLR9 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 9 (TLR9) (AA 99-215) antibodyTLR9 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E8 unconjugated
anti-Toll-Like Receptor 9 (TLR9) (N-Term) antibodyTLR9 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 9 (TLR9) antibodyTLR9 适用: 人 WB, FACS, IHC (p), IF 宿主: 小鼠 Monoclonal 5G5 unconjugated
anti-Toll-Like Receptor 9 (TLR9) antibody (FITC)TLR9 适用: 人 WB, FACS, IHC (p), IF 宿主: 小鼠 Monoclonal 5G5 FITC
anti-Toll-Like Receptor 9 (TLR9) (AA 26-332) antibodyTLR9 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow cytometry: Use at approximately 1:50 dilution. Immunoassays: (detection antibody) Use at approximately 1:50 dilution. Immunohistochemistry: (frozen / paraffin sections) stains RAW macrophages and TLR9 transfected HEK293 cells. Use at aproximately 1:50 dilution. Western blot: Use at approximately 1:50 dilution. The optimal dilution for a specific application should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 1 mL of 100 µg/mL 0.2 µm filtered monoclonal antibody solution in PBS containing protein stabilizer and 0.02% sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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- TLR9 (Toll-Like Receptor 9 (TLR9))
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别名
- CD289 / TLR9
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背景
- Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense of many pathogens. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signalling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. As investigated so far, all functional characterized TLR signals via the TLR/IL-1 receptor (IL-1R) pathway where recruitment of MyD88 seems to be essential. In contrast to cell-wall components, bacterial DNA is probably invisible for immune cells until DNA is liberated during processes taking place in the endosomal/lysosomal compartment where intracellular TLR9 recruits MyD88 to initiate signal transduction. Unmethylated CpG-dinucleotide-containing sequences are found much more frequently in bacterial genomes than in vertebrates genomes, whereas the frequency of CpG dinucleotides are suppressed and usually methylated. The regions adjacent to the CpG dinucleotides also affect the immunostimulatory activity. The optimal sequence differs significantly between mammalian species. Methylated CpG dinucleotides lack immunostimulatory activities. Cellular activation in response to bacterial DNA and synthetic dinucleotides containing unmethylated CpG-dinucleotides is mediated by TLR9.
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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