VAV1 抗体 (AA 121-324)
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Quick Overview for VAV1 抗体 (AA 121-324) (ABIN1845807)
抗原
See all VAV1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 121-324
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
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- VAV1 (Vav 1 Oncogene (VAV1))
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别名
- VAV1
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背景
- The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
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分子量
- 98.3 kDa
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基因ID
- 7409
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UniProt
- P15498
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling
抗原
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