CD33 抗体 (AA 15-237)
Quick Overview for CD33 抗体 (AA 15-237) (ABIN1845398)
抗原
See all CD33 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 15-237
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. coli.
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
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- CD33
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别名
- CD33
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背景
- The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells.Preferentially binds to alpha-2,6-linked sialic acid.The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules.Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD).
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分子量
- 39.8 kDa
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基因ID
- 945
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UniProt
- P20138
抗原
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