ESR2 抗体 (AA 493-504)
Quick Overview for ESR2 抗体 (AA 493-504) (ABIN1820030)
抗原
See all ESR2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 493-504
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特异性
- Recognizes human estrogen receptor beta 5 (ERB5), a splice variant of the nuclear receptor hormone ERbeta (ESR2), shown to exist in at least five isoforms (ERB1-ERB5). Although only the ERB1 variant appears fully functional, the remaining isoforms have been shown to form heterodimers with ERB1, thereby enhancing transcription. Immunohistochemical studies have revealed a ubiquitous expression of ERB5 in normal colorectal tissue, and to be present in all primary colorectal carcinomas studied. Studies also revealed the nuclear expression of ERB5 in the majority of breast carcinomas tested, with a possible association with improved patient survival.
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纯化方法
- Protein G purified
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免疫原
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Tuberculin conjugated synthetic peptide LLSHVRHARYAP derived from the C-terminus of human ERB5. Percent identity by BLAST analysis: Human (100%), Ferret (92%).
Type of Immunogen: Synthetic peptide -
亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Target Species of Antibody: Human
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- PBS, 0.1 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- ESR2 (Estrogen Receptor 2 (ESR2))
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别名
- ESR2 / ER beta
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背景
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Name/Gene ID: ESR2
Subfamily: NR3 Steroid receptor
Family: NHR
Synonyms: ESR2, ESTRB, ER Beta, ERbeta, ER-BETA, ESR-BETA, ESRB, Estrogen receptor 2 (ER beta), NR3A2, Estrogen receptor beta, Estrogen receptor beta 4 -
基因ID
- 2100
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途径
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
抗原
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