SIGLEC-5,SIGLEC-14 抗体
适用: 人
ELISA, FACS, IF, IP
宿主: 小鼠
Monoclonal
1A5
unconjugated
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- 抗原
- SIGLEC-5,SIGLEC-14
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- 非结合性
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应用范围
- ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
- 特异性
- Recognizes human Siglec-5 (Sialic acid-binding Ig-like lectin 5), otherwise known as CD170, a novel sialic-acid-binding Ig-like lectin, and member of the Ig superfamily, expressed by dendritic cells (DCs), activated macrophages, neutrophils, and cells of the monocyte/myeloid lineage. Clone 1A5, is one of several Siglec-5 antibodies which also recognizes human Siglec-14 (Sialic acid-binding Ig-like lectin 14), see for details. Siglec-14 shares an almost identical sequence with Siglec-5 within the first two Ig-like domains, indicating partial gene conversion between these two Siglecs, also evident in other primate species. Siglec-5 is highly related to the myelomonocytic-derived adhesion molecule CD33 (Siglec-3), and mediates sialic-acid dependent binding to cells, as well as acting as an inhibitory receptor in the down-regulation of cell activation. Structurally, Siglec-5 contains an immunoreceptor tyrosine-based inhibitor motif (ITIM), which plays a part in the modulation of cellular responses, and when phosphorylated, can bind to the SH2 domain of several SH2-containing phosphatases. Siglec-14 is a putative sialic-acid binding adhesion molecule, and member of the Ig superfamily, predominantly expressed in hematopoietic tissues, which has been shown to associate with the activating adapter protein DAP12. Clone 1A5 has been show to cross react with Chimpanzee, see for details.
- 纯化方法
- Protein G purified
- 免疫原
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Siglec-5-Fc protein, consisting of the full-length extracellular region of human Siglec-5, fused with the Fc region of human IgG1.
Type of Immunogen: Recombinant protein - 克隆位点
- 1A5
- 亚型
- IgG1
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anti-SIGLEC-5,SIGLEC-14 (Internal Region) antibody
适用: 人 ELISA, IHC (p), WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Target Species of Antibody: Human
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- PBS, 0.09 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- 抗原
- SIGLEC-5,SIGLEC-14
- 别名
- SIGLEC5 + SIGLEC14
- 别名
- SIGLEC5 antibody, sialic acid binding Ig like lectin 14 antibody, SIGLEC14 antibody
- 背景
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Name/Gene ID: SIGLEC5 + SIGLEC14
Synonyms: SIGLEC5 + SIGLEC14
This antibody detects: SIGLEC5 + SIGLEC14 - UniProt
- O15389
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