This Monoclonal antibody 10.1 recognizes Indoleamine-pyrrole 2,3-dioxygenase (IDO), an enzyme responsible for the catabolism of Tryptophan to N-Formlkynurenine and Kynurenine. In Western Blotting, it recognizes a 45 kDa band in IFN-gamma treated Human cell lines. This antibody recognizes a slightly lower Molecular Weight band in Mouse IDO compared to its Human counterpart.
IDO1
适用: 人
WB, IHC, IF
宿主: 兔
Polyclonal
unconjugated
应用备注
Western Blot. Immunohistochemistry on frozen sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
浓度
1.0 mg/mL
缓冲液
PBS, 0.09 % Sodium Azide
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
有效期
12 months
抗原
IDO1
(Indoleamine 2,3-Dioxygenase 1 (IDO1))
别名
IDO1 / INDO
背景
With the exception of tryptophan oxidase in hepatocytes, IDO is the only enzyme that degrades the amino acid tryptophan to kynurenine. Chlamydial pathogens require tryptophan for growth. IDO can lower available tryptophan in target cells leading to conversion of the pathogen to persistant forms, with significance in the progression to chronic infection with its associated pathological effects.Synonyms: 3-dioxygenase, 3-dioxygenase 1, EC=1.13.11.52, IDO, IDO1, INDO, Indoleamine 2, Indoleamine-pyrrole 2