C5AR1 抗体 (AA 15-27)
(3 references)Quick Overview for C5AR1 抗体 (AA 15-27) (ABIN1774738)
抗原
See all C5AR1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 15-27
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原理
- Anti-Hu CD88 Purified
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特异性
- The mouse monoclonal antibody S5/1 recognizes an extracellular epitope of CD88 protein, a 43 kDa receptor of C5a component of the complement cascade.
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交叉反应 （详细）
- Human, Bovine, Ferret, Rabbit
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Recombinant N-terminal peptide (Asp15-Asp27) of human C5aR
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亚型
- IgG2a kappa
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anti-Complement Component 5a Receptor 1 (C5AR1) (C-Term) antibody
Verified C5AR1 适用: 人 WB, FACS, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 1-350) antibodyC5AR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E2 unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 1-36) antibodyC5AR1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 1-350) antibodyC5AR1 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 1-350) antibodyC5AR1 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) antibodyC5AR1 适用: 人, 兔 FACS, IHC, IHC (p), Func, Neut 宿主: 小鼠 Monoclonal unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 15-27) antibody (FITC)C5AR1 适用: 人, Cow, 兔, 雪貂 FACS 宿主: 小鼠 Monoclonal S5-1 FITC
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 15-27) antibody (PE)C5AR1 适用: 人, Cow, 兔, 雪貂 FACS 宿主: 小鼠 Monoclonal S5-1 PE
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 15-27) antibody (APC)C5AR1 适用: 人, Cow, 兔, 雪貂 FACS 宿主: 小鼠 Monoclonal S5-1 APC
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 301-350) antibodyC5AR1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow cytometry: Recommended dilution: 3-12 μg/mL.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "C5a mediates peripheral blood neutrophil dysfunction in critically ill patients." in: American journal of respiratory and critical care medicine, Vol. 180, Issue 1, pp. 19-28, (2009) (PubMed).
: "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)." in: The Journal of biological chemistry, Vol. 277, Issue 9, pp. 7165-9, (2002) (PubMed).
: "Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis." in: Arthritis and rheumatism, Vol. 41, Issue 2, pp. 233-45, (1998) (PubMed).
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: "C5a mediates peripheral blood neutrophil dysfunction in critically ill patients." in: American journal of respiratory and critical care medicine, Vol. 180, Issue 1, pp. 19-28, (2009) (PubMed).
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- C5AR1 (Complement Component 5a Receptor 1 (C5AR1))
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别名
- CD88
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背景
- Complement C5a receptor 1,CD88 / C5aR is a G protein-coupled seven membrane-spanning protein serving as a receptor for C5a component of the complement cascade, and is expressed mainly by monocytes, macrophages, neutrophils, eosinophils, and mast cells, but also e.g. by hepatocytes, glial cells, vascular endothelial cells, or cardiomyocytes. The binding of C5a to CD88 is associated with inflammatory response, including superoxide anion production, chemotaxis, and increased production of acute phase proteins. Expression of CD88 on synovial mast cells and their C5a-mediated degranulation plays a role in pathogenesis of rheumatoid arthritis.,C5A, C5R1, C5AR1
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基因ID
- 728
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UniProt
- P21730
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途径
- Complement System
抗原
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