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Abeta 1-42 抗体

This anti-Abeta 1-42 antibody is a 兔 多克隆 antibody detecting Abeta 1-42 in WB, IHC, ELISA 和 IHC (p). Suitable for 人, 大鼠 和 小鼠. This Primary Antibody has been cited in 6+ publications.
产品编号 ABIN1742444
发货至: 中国

Quick Overview for Abeta 1-42 抗体 (ABIN1742444)

抗原

See all Abeta 1-42 抗体
Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

适用

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人, 大鼠, 小鼠

宿主

  • 27
  • 25
  • 1

克隆类型

  • 27
  • 26
多克隆

标记

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This Abeta 1-42 antibody is un-conjugated

应用范围

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  • 3
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Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 原理

    Rabbit anti-Abeta42 antibody

    特异性

    Specific for Abeta 42

    交叉反应 (详细)

    Reacts with: human (P05067), rat (P08592), mouse (P12023). Other species not tested yet.

    纯化方法

    affinity purified

    免疫原

    Synthetic peptide corresponding to the carboxy terminal part of human Abeta42 (UniProt Id: P05067)
  • 应用备注

    WB:1 : 1000 ,

    说明

    WB: Detects purified Abeta 42. Complex samples like brain extracts still have to be tested. Nitrocellulose membrane is recommended for blotting.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    For reconstitution add 50 μLH2O to get a 1 mg/mL solution in PBS.

    缓冲液

    PBS. Albumin and azide were added for stabilization.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

    储存条件

    -20 °C,-80 °C,4 °C

    储存方法

    Antibodies should be stored at +4°C when still lyophilized. Then aliquot and store at -20°C to -80°C until use. Albumin and azide were added for stabilization. Do not freeze!
  • Wang, Wu, Anand, Karthivashan, Phukan, Yang, Thinakaran, Westaway, Kar: "Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against β-amyloid-toxicity." in: Neuropathology and applied neurobiology, Vol. 46, Issue 7, pp. 686-706, (2021) (PubMed).

    Hüttenrauch, Baches, Gerth, Bayer, Weggen, Wirths: "Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer's disease." in: Journal of Alzheimer's disease : JAD, Vol. 44, Issue 4, pp. 1291-302, (2015) (PubMed).

    Guzmán, Bouter, Richard, Lannfelt, Ingelsson, Paetau, Verkkoniemi-Ahola, Wirths, Bayer: "Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease." in: Molecular neurodegeneration, Vol. 9, pp. 13, (2014) (PubMed).

    Reinert, Martens, Huettenrauch, Kolbow, Lannfelt, Ingelsson, Paetau, Verkkoniemi-Ahola, Bayer, Wirths: "Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models." in: Journal of Alzheimer's disease : JAD, Vol. 39, Issue 4, pp. 871-81, (2014) (PubMed).

    Christensen, Huettenrauch, Mitkovski, Pradier, Wirths: "Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal A? accumulation." in: Frontiers in aging neuroscience, Vol. 6, pp. 139, (2014) (PubMed).

    Bouter, Dietrich, Wittnam, Rezaei-Ghaleh, Pillot, Papot-Couturier, Lefebvre, Sprenger, Wirths, Zweckstetter, Bayer: "N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits." in: Acta neuropathologica, Vol. 126, Issue 2, pp. 189-205, (2013) (PubMed).

  • 抗原

    Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

    别名

    Abeta42

    背景

    Synonyms: Beta-APP, ABPP

    Antigen Information: Abeta peptides are major components of neuritic plaques in Alzheimer's disease

    UniProt

    P05067
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