WHSC2 抗体 (AA 280-511)
(2 references)Quick Overview for WHSC2 抗体 (AA 280-511) (ABIN1724801)
抗原
See all WHSC2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 280-511
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原理
- WHSC2 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. Coli.
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亚型
- IgG2b
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anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody
WHSC2 适用: 人, 大鼠 WB, ELISA, IHC, FACS, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 1-528) antibodyWHSC2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 429-527) antibodyWHSC2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibodyWHSC2 适用: 人 WB, ELISA, IF, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 6B11H8 unconjugated
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome." in: Human molecular genetics, Vol. 21, Issue 10, pp. 2181-93, (2012) (PubMed).
: "Cellular dynamics of the negative transcription elongation factor NELF." in: Experimental cell research, Vol. 315, Issue 10, pp. 1693-705, (2009) (PubMed).
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: "Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome." in: Human molecular genetics, Vol. 21, Issue 10, pp. 2181-93, (2012) (PubMed).
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- WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))
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别名
- WHSC2
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背景
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This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
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分子量
- 57.3 kDa
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基因ID
- 7469
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途径
- Chromatin Binding
抗原
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