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WHSC2 抗体 (AA 280-511)

WHSC2 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 6B11H8 unconjugated
产品编号 ABIN1724801
发货至: 中国
  • 抗原 See all WHSC2 抗体
    WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))
    抗原表位
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 280-511
    适用
    • 39
    • 13
    • 12
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 25
    • 13
    • 1
    小鼠
    克隆类型
    • 29
    • 10
    单克隆
    标记
    • 20
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This WHSC2 antibody is un-conjugated
    应用范围
    • 24
    • 13
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    原理
    WHSC2 Antibody
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. Coli.
    克隆位点
    6B11H8
    亚型
    IgG2b
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/200 - 1/1000

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Kerzendorfer, Hannes, Colnaghi, Abramowicz, Carpenter, Vermeesch, ODriscoll: "Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome." in: Human molecular genetics, Vol. 21, Issue 10, pp. 2181-93, (2012) (PubMed).

    Yung, Narita, Komori, Yamaguchi, Handa: "Cellular dynamics of the negative transcription elongation factor NELF." in: Experimental cell research, Vol. 315, Issue 10, pp. 1693-705, (2009) (PubMed).

  • 抗原
    WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))
    别名
    WHSC2 (WHSC2 产品)
    背景
    This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

    分子量
    57.3 kDa
    基因ID
    7469
    途径
    Chromatin Binding
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