Estrogen Receptor alpha 抗体 (AA 410-592)
-
- 抗原 See all Estrogen Receptor alpha (ESR1) 抗体
- Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
-
抗原表位
- AA 410-592
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This Estrogen Receptor alpha antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 原理
- ER-alpha Antibody
- 纯化方法
- Purified antibody
- 免疫原
- Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. Coli.
- 克隆位点
- 2B7
- 亚型
- IgG1
- Top Product
- Discover our top product ESR1 Primary Antibody
-
-
- 应用备注
- ELISA: 1/10000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- Purified antibody in PBS containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
-
- 抗原
- Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
- 别名
- ER-alpha (ESR1 产品)
- 背景
-
Description: The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells.
Aliases: ER, ESR1, Era, ESRA
- 基因ID
- 2099
- HGNC
- 2099
- UniProt
- P03372
- 途径
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
-