CD74 抗体 (AA 12-28)
Quick Overview for CD74 抗体 (AA 12-28) (ABIN1721492)
抗原
See all CD74 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 12-28
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特异性
- Reacts with human CD74.
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纯化方法
- Purified (protein G)
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免疫原
- Synthetic peptide corresponding to the human CD74 invariant chain (aa 12-28) conjugated to KLH.
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亚型
- IgG1
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anti-HLA-DR-gamma (CD74) (AA 1-106) antibody
CD74 适用: 人 FACS, WB, ELISA, ICC 宿主: 小鼠 Monoclonal 2D1B3 unconjugated
anti-HLA-DR-gamma (CD74) (AA 78-222) antibodyCD74 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) (AA 64-205) antibodyCD74 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 小鼠, 大鼠 IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) (AA 1-106) antibodyCD74 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 2D1B11 unconjugated
anti-HLA-DR-gamma (CD74) (AA 73-232) antibodyCD74 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 人, 小鼠, Baboon FACS, IF, IHC, StM 宿主: 小鼠 Monoclonal LN-2 unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 人 FACS, WB, IF, IHC, IP, ICC 宿主: 小鼠 Monoclonal PIN-1 unconjugated
anti-HLA-DR-gamma (CD74) (N-Term) antibodyCD74 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC (5 μg/mL) IP (12 μg/mL) WB (1 μg/mL) A doublet band of ~33-35 kDa is detected corresponding to the apparent molecular mass of the p33 and p35 forms of human CD74.
Positive control: PALA cell lysate. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 50 % glycerol
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Dilute in PBS or medium that is identical to that used in the assay system.
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储存条件
- -20 °C
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储存方法
- This antibody is stable for at least one year at -20°C. Avoid repeated freezing and thawing.
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- CD74 (HLA-DR-gamma (CD74))
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别名
- CD74
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背景
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CD74 is a non-polymorphic type II integral membrane protein. It has a short N-terminal cytoplasmic tail of 28 amino acids followed by a single 24-aa transmembrane region and an approximately 150-aa lumenal domain. CD74 functions mainly as an MHC class II chaperone which promotes ER exit of MHC class II molecules by directing them to endocytic compartments, preventing peptide binding in the ER, and contributing to peptide "editing" in the MHC class II compartment. CD74 has recently been shown to have a role as an accessory signaling molecule because of its high affinity binding to the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF).
HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain, Ii, p33, CD_antigen: CD74 Gene name : CD74 -
基因ID
- 972
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UniProt
- P04233
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途径
- Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
抗原
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