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SUMO2 抗体

The 兔 多克隆 anti-SUMO2 antibody is suitable to detect SUMO2 in samples from 人. It has been validated for IF, IHC (p) 和 IHC (fro).
产品编号 ABIN1715054
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for SUMO2 抗体 (ABIN1715054)

抗原

See all SUMO2 抗体
SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

适用

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宿主

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克隆类型

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多克隆

标记

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This SUMO2 antibody is un-conjugated

应用范围

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Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 原理

    Sumo2 Polyclonal Antibody

    交叉反应

    人, 小鼠

    预测反应

    Rat,Cow,Pig,Rabbit

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human Sumo2

    亚型

    IgG
  • 应用备注

    IHC-P(1:100-500), IHC-F(1:100-500), IF(1:100-500)

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

    有效期

    12 months
  • 抗原

    SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

    别名

    Sumo 2

    背景

    Synonyms: Small ubiquitin-related modifier 2, SUMO-2, Sumo 2, HSMT3, SMT3 homolog 2, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3A, Smt3A, SUMO2_HUMAN.

    Background: The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease

    基因ID

    6613

    UniProt

    P61956

    途径

    Methionine Biosynthetic Process
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