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ERBB4 抗体 (AA 451-550)

Name: ERBB4 抗体 (AA 451-550)
SKU: ABIN1714916
Availability: OutOfStock

This anti-ERBB4 antibody is a 兔多克隆 antibody detecting ERBB4 in ELISA, IF (cc), IF (p), IHC (p), ICC 和 IHC (fro). Suitable for 人, 小鼠, 大鼠和豚鼠.

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-HER4/ErbB4 Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining (ERBB4 抗体 (AA 451-550))

IHC (p)

Formalin-fixed and paraffin embedded rat kidney labeled with Rabbit Anti-HER4/ErbB4 Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining (ERBB4 抗体 (AA 451-550))

IHC (p)

2 images

产品编号 ABIN1714916

发货至: 中国

Datasheet as PDF

Quick Overview for ERBB4 抗体 (AA 451-550) (ABIN1714916)

抗原

See all ERBB4 抗体

ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

适用

人, 小鼠, 大鼠, 豚鼠

宿主

兔

克隆类型

多克隆

标记

This ERBB4 antibody is un-conjugated

应用范围

ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product ERBB4 Primary Antibody

抗原表位
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AA 451-550

交叉反应

豚鼠, 人, 小鼠, 大鼠

预测反应

Dog,Cow,Sheep,Horse,Rabbit,Goat

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human HER4/ErbB4

亚型

IgG
anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 29-278) antibody
ERBB4 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (C-Term) antibody
ERBB4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (pTyr1284) antibody
ERBB4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 26-160) antibody
ERBB4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 1159-1308) antibody
ERBB4 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5G6B4 unconjugated

anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 1116-1269) antibody
ERBB4 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ERBB4-2581 unconjugated

anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (pTyr1162) antibody
ERBB4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 1116-1269) antibody
ERBB4 适用: 人, 小鼠 IF, FACS 宿主: 小鼠 Monoclonal HFR-1 unconjugated

anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (pTyr1162) antibody
ERBB4 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB5687 unconjugated

anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 1027-1204) antibody
ERBB4 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

别名

HER4/ErbB4

背景

Synonyms: HER4, ALS19, p180erbB4, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, Tyrosine kinase-type cell surface receptor HER4, ERBB4
Background: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration.

基因ID

2066

UniProt

Q15303

途径

RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway