TYROBP 抗体 (AA 31-113)
Quick Overview for TYROBP 抗体 (AA 31-113) (ABIN1714723)
抗原
See all TYROBP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 31-113
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Dog,Cow,Sheep,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human DAP12
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亚型
- IgG
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
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别名
- DAP12
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背景
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Synonyms: DAP 12, DAP12, DNAX activation protein 12, DNAX-activation protein 12, KAR-associated protein, KARAP, Killer activating receptor associated protein, Killer-activating receptor-associated protein, PLOSL, TYOBP_HUMAN, TYRO protein tyrosine kinase binding protein, TYRO protein tyrosine kinase-binding protein, TYROBP.
Background: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70 kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
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基因ID
- 7305
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UniProt
- O43914
抗原
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