HIC1 抗体 (AA 501-650)
(1 reference)Quick Overview for HIC1 抗体 (AA 501-650) (ABIN1714195)
抗原
See all HIC1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 501-650
-
交叉反应
- 小鼠
-
预测反应
- Human,Rat,Dog,Cow,Pig,Horse,Chicken
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human HIC1
-
亚型
- IgG
-
-
anti-Hypermethylated in Cancer 1 (HIC1) (AA 396-453) antibody
HIC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E11 unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 396-453) antibodyHIC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E11 unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 297-418) antibodyHIC1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 193-204) antibodyVerified HIC1 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 899-948) antibodyHIC1 适用: 人, 豚鼠, 犬, Cow, Pig, 猴, 马, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 627-705) antibodyHIC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F2 unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 215-264) antibodyHIC1 适用: 人, 小鼠, 大鼠, 犬, Cow, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 209-258) antibodyHIC1 适用: 人, 小鼠, 大鼠, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 180-430) antibodyHIC1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 1 (HIC1) (AA 180-430) antibodyHIC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
-
有效期
- 12 months
-
-
-
: "Loss of hypermethylated in cancer 1 (HIC1) promotes lung cancer progression." in: Cellular signalling, Vol. 53, pp. 162-169, (2019) (PubMed).
-
: "Loss of hypermethylated in cancer 1 (HIC1) promotes lung cancer progression." in: Cellular signalling, Vol. 53, pp. 162-169, (2019) (PubMed).
-
- HIC1 (Hypermethylated in Cancer 1 (HIC1))
-
别名
- HIC1
-
背景
-
Synonyms: Hic 1, Hic-1, Hic1, HIC1_HUMAN, Hypermethylated in cancer 1, Hypermethylated in cancer 1 protein, ZBTB29, Zinc finger and BTB domain-containing protein 29, ZNF901.
Background: Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing. These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression. HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. Conversely, HIC-1 does not interact with components of the HDAC complex, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain.
-
基因ID
- 3090
-
途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
-
