Perforin 1 抗体 (AA 22-100)
Quick Overview for Perforin 1 抗体 (AA 22-100) (ABIN1713880)
抗原
See all Perforin 1 (PRF1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 22-100
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交叉反应
- 小鼠, 大鼠
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预测反应
- Human,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Perforin
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亚型
- IgG
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anti-Perforin 1 (Pore Forming Protein) (PRF1) (AA 280-555) antibody
PRF1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Perforin 1 (Pore Forming Protein) (PRF1) antibodyPRF1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Perforin 1 (Pore Forming Protein) (PRF1) (AA 461-555) antibodyPRF1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3B4 unconjugated
anti-Perforin 1 (Pore Forming Protein) (PRF1) antibodyPRF1 适用: 人, Cow IP, FACS, ICC, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal dG9 unconjugated
anti-Perforin 1 (Pore Forming Protein) (PRF1) (AA 40-355) antibodyPRF1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Perforin 1 (Pore Forming Protein) (PRF1) (AA 413-552) antibodyPRF1 适用: 人 IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal PRF1-2470 unconjugated
anti-Perforin 1 (Pore Forming Protein) (PRF1) antibody (FITC)PRF1 适用: 人, Cow ICFC 宿主: 小鼠 Monoclonal dG9 FITC
anti-Perforin 1 (Pore Forming Protein) (PRF1) antibody (APC)PRF1 适用: 人, Cow ICFC 宿主: 小鼠 Monoclonal dG9 APC
anti-Perforin 1 (Pore Forming Protein) (PRF1) (AA 32-316) antibodyPRF1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Perforin 1 (Pore Forming Protein) (PRF1) (AA 21-554) antibodyPRF1 适用: 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
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别名
- Perforin
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背景
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Synonyms: Cytolysin, FLH2, HPLH2, Lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1, PERF_HUMAN, Perforin 1, Perforin 1 precursor, Perforin 1 preforming protein, Perforin-1, PFP, PGFL, PIGF, PIGF-2, PLGF, Pore forming protein, PRF 1, PRF1, SHGC-10760.
Background: The major defense of the body against virus-infected and tumorigenic cells is cytotoxic T lymphocyte (CTL)-mediated cytotoxicity, which also plays a role in autoimmune diseases and transplant rejection. During CTL-mediated cytotoxicity, CTL granules containing perforin are exocytosed. Perforin is a pore-forming protein that facilitates the entry of cytotoxic serine proteases, such as granzymes, into target cells by forming transmembrane channels in target cell membranes. Perforin is primarily expressed in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, but has also been observed in an astrocyte population of the human brain. It has been shown that abrogation of perforin function by Ca2+-complexing agents leads to decreased levels of necrosis, demonstrating that both necrosis and apoptosis contribute to CTL-mediated cytotoxicity. Perforin activity has been shown to be induced by IL-2, IL-3, IL-4, IL-6 and to a lesser degree, TNF and IFN-_.
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基因ID
- 5551
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途径
- Apoptosis, Caspase Cascade in Apoptosis
抗原
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