GPBAR1 抗体 (PE-Cy7)
Quick Overview for GPBAR1 抗体 (PE-Cy7) (ABIN1713211)
抗原
See all GPBAR1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human GPBAR1
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亚型
- IgG
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anti-G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) (C-Term) antibody
GPBAR1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) (Cytoplasmic Domain) antibodyGPBAR1 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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FCM(1:100-500)
Optimal working dilution should be determined by the investigator. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))
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别名
- GPCR TGR5/GPBAR1
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背景
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Synonyms: BG 37, BG37, G protein coupled bile acid receptor 1, G protein coupled bile acid receptor BG 37, G protein coupled bile acid receptor BG37, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, GPBAR 1, GPBAR_HUMAN, GPBAR1, GPCR 19, GPCR, GPCR19, GPR 131, GPR131, hBG 37, hBG37, hGPCR 19, hGPCR19, M BAR, M-BAR, Membrane bile acid receptor, Membrane type receptor for bile acids, Membrane-type receptor for bile acids, MGC40597, TGR 5, TGR5.
Background: The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart, skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung. TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalization, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.
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基因ID
- 151306
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途径
- WNT signaling, Hormone Transport, Sensory Perception of Sound
抗原
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