FANCM 抗体 (AA 831-930) (HRP)
Quick Overview for FANCM 抗体 (AA 831-930) (HRP) (ABIN1711008)
抗原
See all FANCM 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 831-930
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预测反应
- Human
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human FANCM
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亚型
- IgG
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anti-Fanconi Anemia Complementation Group M (FANCM) (Internal Region) antibody
FANCM 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fanconi Anemia Complementation Group M (FANCM) (AA 1-669) antibodyFANCM 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Fanconi Anemia Complementation Group M (FANCM) (AA 1752-1783) antibodyFANCM 适用: 人 WB 宿主: 兔 Polyclonal RB54125 unconjugated
anti-Fanconi Anemia Complementation Group M (FANCM) (AA 390-660) antibodyFANCM 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- FANCM (Fanconi Anemia Complementation Group M (FANCM))
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别名
- FANCM
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背景
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Synonyms: FAAP250, Fanconi anemia group M protein, Protein Hef ortholog,
Background: Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. The thirteen FA proteins that have been characterized are important for regulating chromosomal stability and genome surveillance. Eight of these proteins, namely FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM, comprise the FA core complex, which catalyzes a key reaction in DNA repair: the monoubiquitination of FANCD2. FANCM (Fanconi anemia, complementation group M) is a member of the DEAD-box helicase family of proteins and contains a DEAH helicase domain and a nuclease domain. Localizing to chromatin fractions, FANCM is phosphorylated in a cell cycle-dependent manner and is believed to function as an anchor, recruiting the FA core complex to chromatin. Mutations in the gene encoding FANCM can lead to Fanconi anemia.
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基因ID
- 57697
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途径
- DNA Damage Repair
抗原
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