C5 抗体 (Cy7)
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北京 101111
Quick Overview for C5 抗体 (Cy7) (ABIN1707618)
抗原
See all C5 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Complement C5b Polyclonal Antibody, Cy7 Conjugated
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交叉反应
- 人
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预测反应
- Mouse,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human C5
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亚型
- IgG
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anti-Complement Component 5 (C5) (N-Term) antibody
C5 适用: 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5 (C5) (AA 701-755) antibodyC5 适用: 小鼠 WB, IF (p), IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5 (C5) (AA 253-281), (N-Term) antibodyC5 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21866 unconjugated
anti-Complement Component 5 (C5) (AA 253-281) antibodyC5 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5 (C5) (C-Term) antibodyC5 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5 (C5) (AA 1-77) antibodyC5 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5 (C5) (AA 253-281), (N-Term) antibodyC5 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5 (C5) (AA 1550-1661) antibodyC5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB(1:300-5000)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- C5 (Complement Component 5 (C5))
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背景
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Synonyms: Complement C5,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4,Complement C5 alpha chain,Complement C5 alpha' chain
Background: The complement component proteins: C2, C3, C4 and C5 are potent anaphyl-atoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. Activation of the complement system leads to the formation of C5b-9 terminal complex, and while C5b-9 can promote cell lysis, the sublytic assembly of C5b-9 on plasma membranes causes an opposite result and induces cell cycle activation and survival. C5b-9 can rescue oligodendrocytes from FAS-mediated apoptosis by regulating caspase-8 processing via PI 3-K signaling. C5b-9 may play a pro-inflammatory role in the acute phase of multiple sclerosis, but may also be neuroprotective during the chronic phase of the disease. Complement C5 precursor contains C5a anaphylatoxin. C3a and C5a secretion correlates with pathophysiological phenotypes such as asthma and bacterial meningitis.
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基因ID
- 727
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UniProt
- P01031
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途径
- Complement System, Carbohydrate Homeostasis
抗原
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